S-Adenosylmethionine protects against acetaminophen-induced hepatotoxicity in mice

Pharmacology
Zhenyuan SongTheresa S Chen

Abstract

An overdose of acetaminophen (APAP) is the most frequent cause of fulminant liver failure in the United States. Increasing evidence demonstrates that oxidative stress plays an important etiologic role in APAP-induced liver injury. S-Adenosylmethionine (SAMe) is a key intermediate in the hepatic trans-sulfuration pathway and serves as a precursor for glutathione (GSH) as well as the methyl donor in most transmethylation reactions. In the present study, we investigated effects of SAMe on liver injury induced by APAP administration in male C57BL/6 mice. Two related studies were performed. In the first experiment, SAMe (1g/kg BW) was injected intraperitoneally 4 h before APAP (600 mg/kg BW) administration. In the second experiment, SAMe was injected intraperitoneally 1 h after APAP administration. Our results showed that APAP administration induced changes typical of confluent centrilobular necrosis by histological examination and a marked elevation in serum alanine aminotransferase (ALT) activity. APAP administration induced significant decreases in both hepatic and blood SAMe concentrations. In addition, APAP decreased intracellular (both cytosolic and mitochondrial) GSH concentrations along with increased lipid peroxidation in c...Continue Reading

Citations

May 19, 2009·Archives of Toxicology·Arthur I CederbaumDefeng Wu
Mar 2, 2006·Digestive Diseases·Ina BergheimGavin E Arteel
Aug 2, 2008·Biological & Pharmaceutical Bulletin·Yan-Ling WuJi-Xing Nan
Nov 18, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Evan Prince SabinaMahaboobkhan Rasool
Sep 26, 2009·Journal of Pharmaceutical Sciences·Eric J WagnerTimothy D Heath
Jun 27, 2008·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Cheng-chin HsuMei-chin Yin
May 13, 2008·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Jinchun SunRichard D Beger
Mar 13, 2016·Chemico-biological Interactions·Yongchun ZhangZhongxi Zhao
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·Craig McClainDaniell Hill
Sep 14, 2007·Alcoholism, Clinical and Experimental Research·Jesus A VillanuevaCharles H Halsted
Feb 2, 2008·Chemico-biological Interactions·Jae Kyung KimJu Woon Lee
Sep 27, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Cheng-Chin HsuMei-Chin Yin
Apr 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jun-Nan HuYing-Ping Wang
Jan 9, 2017·The Veterinary Clinics of North America. Small Animal Practice·Nick Bexfield
Jul 10, 2007·The American Journal of Clinical Nutrition·Vishnudutt PurohitSamir Zakhari
Jul 9, 2010·The Journal of Pharmacy and Pharmacology·Mahaboob Khan RasoolJaisy Samuel
Jul 27, 2007·Alternatives to Laboratory Animals : ATLA·Halka LotkováPavla Kriváková
Jun 16, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Muhammad Torequl IslamJavad Sharifi-Rad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Related Papers

Pharmacological Research : the Official Journal of the Italian Pharmacological Society
Ayman M Gamal el-dinMahmoud N Nagi
Journal of Biochemical and Molecular Toxicology
Helieh S OzTheresa S Chen
Hepatology : Official Journal of the American Association for the Study of Liver Diseases
G P BrayR Williams
© 2022 Meta ULC. All rights reserved