PMID: 16614485Apr 15, 2006Paper

S-allyl cysteine attenuated CCl4-induced oxidative stress and pulmonary fibrosis in rats

BioFactors
Shinjiro MizuguchiShigefumi Suehiro

Abstract

This study examined effects of S-allyl cysteine (SAC) on carbon tetrachloride (CCl4)-induced interstitial pulmonary fibrosis in Wistar rats. CCl4 (0.5 ml/kg) was intraperitoneally injected into rats twice a week for 8 weeks, and SAC (50, 100, or 200 mg/kg), N-acetyl cysteine (NAC, 200 or 600 mg/kg), or L-cysteine (CYS, 600 mg/kg) were orally administrated to rats everyday for 8 weeks. SAC significantly reduced the increases of transforming growth factor beta, lipid peroxides, AST, and ALT in plasma, induced by CCl4. Although CCl4 is mainly metabolized by hepatic cytochrome P450, CCl4 induced systemic inflammation and some organ fibrosis. SAC dose-dependently and significantly attenuated CCl4-induced systemic inflammation and fibrosis of lung. SAC also inhibited the decrease of thiol levels, the increase of inducible nitric oxide synthase expression, the infiltration of leukocytes, and the generation of reactive oxygen species in lungs. Although NAC and CYS attenuated CCl4-induced pulmonary inflammation and fibrosis, the order of preventive potency was SAC > NAC > CYS according to their applied doses. These results indicate that SAC is more effective than other cysteine compounds in reducing CCl4-induced lung injury, and might b...Continue Reading

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Citations

Jul 13, 2013·Chemico-biological Interactions·Anca HermeneanAnca Dinischiotu
Dec 8, 2009·American Journal of Respiratory and Critical Care Medicine·Changsuk MoonJihee Lee Kang
Nov 21, 2014·Journal of Clinical Biochemistry and Nutrition·Shigekazu TakemuraYukiko Minamiyama
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Sep 4, 2020·Phytotherapy Research : PTR·Sai Manohar ThotaVenketesh Sivaramakrishnan
Jul 2, 2019·Journal of Nutritional Science and Vitaminology·Yo Tsuchiya, Koichi Kawamata

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