S-Allylcysteine reduces breast tumor cell adhesion and invasion

Biochemical and Biophysical Research Communications
Leslie A GapterKa-Yun Ng

Abstract

Previous studies show that aqueous garlic extract and its derivatives (e.g. S-allylcysteine [SAC]) prevent carcinogen-induced breast tumorigenesis. However, investigations testing the effect of SAC on later stages of breast tumorigenesis and/or metastasis have produced mixed results. Here we show that SAC significantly reduced anchorage-dependent and -independent growth of MDA-MB-231 breast tumor cells in a dose- and time-dependent fashion, and sub-lethal SAC-treatment altered mammary tumor cell adhesion and invasion through components of the extracellular matrix. We provide evidence to suggest increased expression of E-cadherin and reduced MMP-2 expression and activity are partially responsible for inhibition of mammary tumor cell invasion by SAC. Because E-cadherin and MMP-2 are important in cancer metastasis, these results suggest a link between SAC induction of E-cadherin and reduction of MMP2 activity with the inhibition of cell motility and invasion; thus providing evidence that events leading to breast cancer metastasis are repressed by sub-lethal SAC-treatment.

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Citations

Jun 26, 2008·Human Genetics·Philippe M CampeauMarc D Tischkowitz
Nov 20, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Amir FeilyMarym Saboktakin
May 9, 2019·Environmental Toxicology·Sujan ChatterjeeKaustav Dutta Chowdhury
Feb 12, 2020·International Journal of Molecular Sciences·Patrycja Bronowicka-AdamskaMaria Wróbel
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Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Arijit MondalAnupam Bishayee

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