S-nitrosation of thioredoxin in the nitrogen monoxide/superoxide system activates apoptosis signal-regulating kinase 1

Archives of Biochemistry and Biophysics
Inna M YasinskaVadim V Sumbayev

Abstract

In the present study, we have investigated S-nitrosation of reactive thioredoxin (Trx) thiol groups in nitric oxide/superoxide system. We have found that Trx thiol groups are the targets for S-nitrosation by N2O3-like species generated in the system containing xanthine/xanthine oxidase (superoxide producing system) and DEA/NO-the *NO donating compound, however, they have shown low sensitivity to the *NO derived from DEA/NO. N2O3-dependent S-nitrosation of Trx at approximately 2-fold of NO excess compared to the superoxide amount resulted in dissociation and activation of apoptosis signal regulating kinase 1 (ASK1). However, approximately 4-fold of NO excess compared to a superoxide production preserved the level of dissociated ASK1 but decreased its activity due to the enzyme S-nitrosation.

Citations

May 27, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Vadim V Sumbayev, Sally A Nicholas
Mar 31, 2005·Archives of Biochemistry and Biophysics·Vadim V Sumbayev, Inna M Yasinska
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Moran BenharJonathan S Stamler
Sep 22, 2006·Antioxidants & Redox Signaling·Junhui SunElizabeth Murphy
Sep 22, 2006·Antioxidants & Redox Signaling·James A McCubreyRichard A Franklin
Oct 8, 2008·Antioxidants & Redox Signaling·Po Sing Leung, Yuk Cheung Chan
Apr 26, 2012·Antioxidants & Redox Signaling·Erin M G Allen, John J Mieyal
Sep 9, 2005·Critical Care Medicine·Steven M Dudek, Konstantin G Birukov
Mar 25, 2006·Circulation Research·Chaoming ZhouEdwin S Levitan
May 14, 2008·Nitric Oxide : Biology and Chemistry·Lissbeth LeonAli Bettaieb
Mar 8, 2008·Biochemical and Biophysical Research Communications·Maristela TsujitaRoberto J Arai
Oct 9, 2015·Redox Biology·Stéphanie PlenchetteAli Bettaieb
Jun 13, 2006·Scandinavian Journal of Immunology·V V Sumbayev, I M Yasinska
Nov 28, 2006·Biochimica Et Biophysica Acta·James A McCubreyRichard A Franklin
Apr 22, 2008·Methods in Enzymology·Vadim V Sumbayev, Inna M Yasinska
Jun 1, 2008·Proteomics. Clinical Applications·Axel GödeckeMichael Reinartz

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