S-nitrosothiol repletion by an inhaled gas regulates pulmonary function

Proceedings of the National Academy of Sciences of the United States of America
Martin P MoyaJonathan S Stamler

Abstract

NO synthases are widely distributed in the lung and are extensively involved in the control of airway and vascular homeostasis. It is recognized, however, that the O(2)-rich environment of the lung may predispose NO toward toxicity. These Janus faces of NO are manifest in recent clinical trials with inhaled NO gas, which has shown therapeutic benefit in some patient populations but increased morbidity in others. In the airways and circulation of humans, most NO bioactivity is packaged in the form of S-nitrosothiols (SNOs), which are relatively resistant to toxic reactions with O(2)/O(2)(-). This finding has led to the proposition that channeling of NO into SNOs may provide a natural defense against lung toxicity. The means to selectively manipulate the SNO pool, however, has not been previously possible. Here we report on a gas, O-nitrosoethanol (ENO), which does not react with O(2) or release NO and which markedly increases the concentration of indigenous species of SNO within airway lining fluid. Inhalation of ENO provided immediate relief from hypoxic pulmonary vasoconstriction without affecting systemic hemodynamics. Further, in a porcine model of lung injury, there was no rebound in cardiopulmonary hemodynamics or fall in ...Continue Reading

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References

Jan 1, 1985·Journal of Free Radicals in Biology & Medicine·M P DoyleR L Dykstra
Feb 1, 1994·American Journal of Respiratory and Critical Care Medicine·B GastonJ S Stamler
Jun 1, 1995·Annals of Medicine·P J Barnes
Oct 1, 1993·Thorax·P J Barnes, M G Belvisi
Jun 26, 1993·Lancet·G A Caron
Jun 26, 1993·Lancet·M HögmanG Hedenstierna
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B GastonD J Singel
May 14, 1996·Proceedings of the National Academy of Sciences of the United States of America·D I SimonJ S Stamler
Aug 1, 1996·Nuclear Medicine and Biology·T J McCarthyM J Welch
Jan 15, 1998·Critical Care Medicine·M A MatthayC Jayr
Mar 7, 1998·The Journal of Biological Chemistry·B MayerF Brunner
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·J C ZhuangG N Wogan
Dec 5, 1998·Biochemical and Biophysical Research Communications·K FangB Gaston
Jan 27, 1999·Biochemical and Biophysical Research Communications·B GastonJ S Stamler
Mar 23, 1999·Nature Medicine·J M Hare, J S Stamler
Aug 4, 1999·Proceedings of the National Academy of Sciences of the United States of America·A J GowJ S Stamler
Nov 11, 1999·Cell Death and Differentiation·B BrüneK B Sandau
Feb 2, 2000·Biochemistry·J P EuJ S Stamler
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·H E Marshall, J S Stamler
Mar 24, 2000·Applied Occupational and Environmental Hygiene·N PavelchakG Casey
May 12, 2000·American Journal of Respiratory and Critical Care Medicine·J ChristensonJ B Hall

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Citations

Sep 18, 2002·Archives of Biochemistry and Biophysics·Brian M MorrisseyDavid M Rodman
Jul 20, 2002·Lancet·Martin P MoyaJonathan S Stamler
May 3, 2003·Trends in Molecular Medicine·Matthew W FosterJonathan S Stamler
Jan 15, 2005·Antioxidants & Redox Signaling·Niki L ReynaertYvonne M W Janssen-Heininger
Feb 1, 2007·Anesthesiology·Mali MathruJohn D Lang
Jan 15, 2005·Annals of Surgery·Nishath Athar AliJames D Reynolds
Apr 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Olivia M GranilloRichard L Auten
Dec 26, 2001·American Journal of Respiratory and Critical Care Medicine·K J SullivanJ J Lima
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Ashley H SnyderBenjamin Gaston
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Richard L AutenKathryn M Auten
Mar 26, 2008·American Journal of Respiratory and Critical Care Medicine·Andrew Bush
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Harvey E MarshallRichard L Auten
Jul 23, 2003·American Journal of Respiratory Cell and Molecular Biology·Elena N AtochinaAndrew J Gow
Aug 6, 2011·American Journal of Respiratory Cell and Molecular Biology·Nadzeya V MarozkinaBenjamin Gaston
Mar 28, 2006·Proceedings of the American Thoracic Society·Timothy J McMahon, Allan Doctor
Jun 9, 2004·Treatments in Respiratory Medicine·Siobhan A Mulrennan, Anthony E Redington
Oct 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Timothy J McMahonJonathan S Stamler
Jun 30, 2004·The Annals of Thoracic Surgery·Ben M TsaiDaniel R Meldrum
Sep 4, 2008·Expert Opinion on Emerging Drugs·Anne Greenough
Sep 8, 2012·Clinics in Perinatology·Thomas M RaffayJames D Reynolds
Jan 21, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Pierre SonveauxOlivier Feron
Mar 4, 2008·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Pierre Sonveaux
Sep 20, 2011·The Journal of Pediatrics·Sripriya Sundararajan, Benjamin Gaston
Feb 19, 2013·Biochimica Et Biophysica Acta·Katarzyna A BroniowskaNeil Hogg
Apr 29, 2010·Free Radical Biology & Medicine·Mulugu V BrahmajothiRichard L Auten
May 1, 2010·Journal of Pharmacological Sciences·Xiling WuRuyi Li
Feb 11, 2015·Annual Review of Physiology·Nadzeya V Marozkina, Benjamin Gaston
Aug 4, 2016·Molecular Pharmacology·Thomas M RaffayBenjamin Gaston
Jan 8, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·Michael E PriceJoseph H Sisson
Jul 13, 2004·American Journal of Physiology. Lung Cellular and Molecular Physiology·Andrew J GowHarry Ischiropoulos
Jul 23, 2004·Physiological Reviews·Fabio L M RicciardoloGert Folkerts
Sep 15, 2001·Nature·S A Lipton
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Elena N Atochina-VassermanAndrew J Gow
Dec 15, 2017·Clinical Pharmacology and Therapeutics·James D ReynoldsJonathan S Stamler
Dec 9, 2020·Pediatric Pulmonology·Vikram BhatiaShyamala Dakshinamurti
Mar 30, 2021·American Journal of Respiratory Cell and Molecular Biology·Thomas M RaffayBenjamin Gaston

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