S-nitrosothiol signaling in respiratory biology

American Journal of Respiratory and Critical Care Medicine
Benjamin GastonJonathan S Stamler

Abstract

Genetic and biochemical data demonstrate a pivotal role for S-nitrosothiols (SNOs) in mediating the actions of nitric oxide synthases (NOSs). SNOs serve to convey NO bioactivity and to regulate protein function. This understanding is of immediate interest to the pulmonary clinical and research communities. This article reviews the following: (1) biochemical and cellular evidence that SNOs in amino acids, peptides, and proteins elicit NOS-dependent signaling in the respiratory system and (2) studies that link SNO signaling to pulmonary medicine. SNO-mediated signaling is involved in the regulation of minute ventilation, ventilation-perfusion matching, pulmonary arterial pressure, basal airway tone, and respiratory and peripheral muscle function. Derangements in SNO signaling are implicated in many disorders relevant to pulmonary and critical care medicine, including apnea, hypoxemia, pulmonary hypertension, asthma, cystic fibrosis, pneumonia, and septic shock.

References

Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·B GastonD J Singel
Aug 2, 1996·The Journal of Biological Chemistry·R J SinghB Kalyanaraman
Apr 15, 1997·The Biochemical Journal·N HoggB Kalyanaraman
Nov 14, 1997·Anesthesiology·A M Atz, D L Wessel
Nov 21, 1997·Biochemical and Biophysical Research Communications·E F FunaiT H Finlay
Mar 7, 1998·The Journal of Biological Chemistry·B MayerF Brunner
Apr 4, 1998·American Journal of Respiratory Cell and Molecular Biology·J D FortenberryL A Brown
May 9, 1998·The Journal of Biological Chemistry·M TrujilloR Radi
Mar 10, 1999·The American Journal of Physiology·J D FortenberryL A Brown
Jul 17, 1999·The American Journal of Physiology·T JillingS Matalon
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·L J JanssenS Keshavjee
Feb 24, 2001·Nature·J R PawloskiJ S Stamler
Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·R A DweikS C Erzurum
Aug 9, 2001·Proceedings of the National Academy of Sciences of the United States of America·N RamachandranB Mutus
Sep 12, 2001·The Journal of Cell Biology·J B MannickB Gaston
Sep 15, 2001·Nature·A J LiptonB Gaston
Jan 18, 2002·The Journal of Biological Chemistry·Andrew J GowJonathan S Stamler
Apr 6, 2002·American Journal of Respiratory and Critical Care Medicine·Ashley H SnyderBenjamin Gaston
Apr 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Eva Nozik-GrayckClaude A Piantadosi
May 2, 2002·Proceedings of the National Academy of Sciences of the United States of America·Olga RafikovaEvgeny Nudler
Jun 4, 2002·Nature Medicine·Timothy J McMahonJonathan S Stamler
Jul 20, 2002·Lancet·Martin P MoyaJonathan S Stamler
Sep 13, 2002·American Journal of Physiology. Cell Physiology·Ashish K Gupta, Bruce C Kone
Sep 24, 2002·Nature Cell Biology·Judith HaendelerStefanie Dimmeler
Oct 12, 2002·American Journal of Physiology. Lung Cellular and Molecular Physiology·Thomas A WhiteMathur S Kannan
May 2, 2003·Nature Medicine·Tienush RassafMartin Feelisch
Oct 4, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Wangsen CaoWalter F Mangel
Nov 8, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Sadis MatalonJonathan S Stamler
Dec 3, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jerry P EuJonathan S Stamler
Jun 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Niki L ReynaertYvonne M W Janssen-Heininger
Jul 23, 2004·Physiological Reviews·Fabio L M RicciardoloGert Folkerts
Jan 20, 2005·The Journal of General Physiology·Wei WangKevin L Kirk

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Citations

Apr 20, 2010·Amino Acids·Corinne M Spickett, Andrew R Pitt
Sep 4, 2009·Archives of Pharmacal Research·Wilmarie Flores-SantanaDavid A Wink
Aug 4, 2010·Journal of the American Chemical Society·Adam FaccendaBulent Mutus
Oct 9, 2008·Nature Medicine·Lisa A PalmerBenjamin Gaston
Apr 5, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pablo R CastelloRobert O Poyton
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Nadzeya V MarozkinaKhalequz Zaman
Oct 2, 2008·The Journal of Biological Chemistry·Raynard L BatemanKevan M Shokat
May 21, 2011·Journal of Toxicology and Environmental Health. Part a·Travis L KnucklesMatthew J Campen
Feb 24, 2010·The Journal of General Physiology·Jose F Perez-ZoghbiMichael J Sanderson
May 19, 2007·Antioxidants & Redox Signaling·Donald G Buerk
Jul 12, 2012·Bioinformatics·Tzong-Yi LeeYu-Ju Chen
Dec 30, 2008·Plant & Cell Physiology·Mounira ChakiJuan B Barroso
Aug 2, 2007·Journal of Cardiovascular Pharmacology·Maleka P Hashmi-HillStephen J Lewis
Sep 9, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Somshuvra MukhopadhyayPravin B Sehgal
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Jason LeePravin B Sehgal
Aug 4, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Pravin B SehgalSonia C Flores
Oct 5, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth KleinSandra M Wells
Apr 29, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Olivia M GranilloRichard L Auten
Mar 31, 2011·International Archives of Allergy and Immunology·Byung-Jae LeeDong-Chull Choi
Sep 2, 2008·Circulation Research·Nadzeya MarozkinaAllan Doctor
Apr 22, 2006·American Journal of Respiratory and Critical Care Medicine·Hartmut GrasemannFelix Ratjen
Nov 18, 2006·American Journal of Respiratory and Critical Care Medicine·Abigail S JacksonDeborah H Yates
May 5, 2007·American Journal of Respiratory and Critical Care Medicine·Richard L AutenKathryn M Auten
Mar 27, 2007·American Journal of Respiratory and Critical Care Medicine·Wendy C Moore, Stephen P Peters
Aug 25, 2007·American Journal of Respiratory and Critical Care Medicine·Dave SinghBrian J O'Connor
Mar 28, 2009·American Journal of Respiratory and Critical Care Medicine·Harvey E MarshallRichard L Auten
Jul 28, 2009·American Journal of Respiratory and Critical Care Medicine·Stephen J Lewis, Benjamin Gaston
Jul 14, 2010·American Journal of Respiratory and Critical Care Medicine·Yvonne P de VisserGerry T M Wagenaar
May 21, 2011·American Journal of Respiratory and Critical Care Medicine·Nadzeya V Marozkina, Benjamin Gaston
Jun 2, 2007·American Journal of Respiratory Cell and Molecular Biology·D Jeannean CarverLisa A Palmer
Mar 4, 2008·American Journal of Respiratory Cell and Molecular Biology·Lan ChenSadis Matalon
May 19, 2009·American Journal of Respiratory Cell and Molecular Biology·Lester Kobzik
Mar 30, 2010·American Journal of Respiratory Cell and Molecular Biology·Amy M PastvaJo Rae Wright
Aug 6, 2011·American Journal of Respiratory Cell and Molecular Biology·Nadzeya V MarozkinaBenjamin Gaston
Feb 11, 2012·American Journal of Respiratory Cell and Molecular Biology·Jordan A TorokTimothy J McMahon
Sep 6, 2007·The Journal of Clinical Investigation·Lisa A PalmerBenjamin Gaston
Jan 3, 2013·The Journal of Clinical Investigation·Saptarsi M Haldar, Jonathan S Stamler
Dec 17, 2009·Hematology·Joshua J Field, Michael R DeBaun
Jun 13, 2006·Respiratory Research·Hartmut GrasemannFelix Ratjen
Nov 27, 2009·Environmental Health : a Global Access Science Source·Chad M Thompson, Roland C Grafström
Nov 15, 2008·PLoS Biology·Chang-Jiang GuoAndrew J Gow

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