S-Nitrosylation Regulates Cell Survival and Death in the Central Nervous System

Neurochemical Research
Yoshiki Koriyama, Ayako Furukawa

Abstract

Nitric oxide (NO), which is produced from nitric oxide synthase, is an important cell signaling molecule that is crucial for many physiological functions such as neuronal death, neuronal survival, synaptic plasticity, and vascular homeostasis. This diffusible gaseous compound functions as an effector or second messenger in many intercellular communications and/or cell signaling pathways. Protein S-nitrosylation is a posttranslational modification that involves the covalent attachment of an NO group to the thiol side chain of select cysteine residues on target proteins. This process is thought to be very important for the regulation of cell death, cell survival, and gene expression in the central nervous system (CNS). However, there have been few reports on the role of protein S-nitrosylation in CNS disorders. Here, we briefly review specific examples of S-nitrosylation, with particular emphasis on its functions in neuronal cell death and survival. An understanding of the role and mechanisms underlying the effects of protein S-nitrosylation on neurodegenerative/neuroprotective events may reveal a novel therapeutic strategy for rescuing neurons in neurodegenerative diseases.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Aug 18, 1993·Biochimica Et Biophysica Acta·H H SchmidtU Walter
Apr 1, 1997·Experimental Neurology·M N WallaceM R Masson
Oct 6, 2000·Nitric Oxide : Biology and Chemistry·E M GattoJ J Poderoso
Feb 15, 2001·Nature Cell Biology·S R JaffreyS H Snyder
Apr 28, 2001·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·G C Chiou
Mar 6, 2002·The European Journal of Neuroscience·V C StewartS J R Heales
Aug 21, 2002·Current Eye Research·Toru NakazawaMakoto Tamai
May 30, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Kwon-Soo HaYoung-Myeong Kim
Jun 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T AudesirkG Audesirk
Mar 27, 2004·European Journal of Pharmacology·Matsumi YamazakiHiroshi Hatanaka
Apr 1, 2006·Biochimica Et Biophysica Acta·Makoto R HaraAkira Sawa
Aug 2, 2006·Annual Review of Pharmacology and Toxicology·Makoto R Hara, Solomon H Snyder
Apr 3, 2007·British Journal of Pharmacology·M R Miller, I L Megson
Nov 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jianguo FangStuart A Lipton
Dec 8, 2007·Free Radical Biology & Medicine·Barbara J BuckleyA Richard Whorton
Jul 1, 2008·The European Journal of Neuroscience·John Garthwaite
Jul 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jing TianSolomon H Snyder
Aug 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Chun-Qi LiGerald N Wogan
Dec 5, 2009·The EMBO Journal·Alfredo CriolloGuido Kroemer
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hossein AleyasinDavid S Park
Jul 31, 2010·Molecular Cell·Tomohiro NakamuraStuart A Lipton

❮ Previous
Next ❯

Citations

Apr 4, 2019·Future Medicinal Chemistry·Filippo BasagniMichela Rosini
Apr 4, 2020·Naunyn-Schmiedeberg's Archives of Pharmacology·Elizabeth Arlen Pineda-PeñaAndrés Navarrete
Oct 6, 2020·The Biochemical Journal·Salvatore Rizza, Giuseppe Filomeni

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
acetylation
nuclear translocation

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.