PMID: 3527993Sep 15, 1986Paper

S-phase fraction of human brain tumors in situ measured by uptake of bromodeoxyuridine

International Journal of Cancer. Journal International Du Cancer
T HoshinoL H Pitts

Abstract

One hundred fifty-four patients with brain tumors of various types were given an intravenous infusion of the thymidine analogue bromodeoxyuridine (BUdR), 200 mg/m2, at the time of surgery but before biopsy of the tumor to label S-phase cells. Excised tumor specimens were fixed, sectioned, and stained by immunoperoxidase methods to detect BUdR. The labelling index (LI), or percentage of BUdR-labelled cells, was calculated for each tumor specimen. The LIs of glioblastomas, medulloblastomas, and most highly anaplastic astrocytomas were 5% to 20%. The majority of moderately anaplastic astrocytomas showed LIs of less than 1%, but 30% of them had LIs similar to those of highly malignant gliomas. Most pituitary adenomas and neurinomas showed LIs of less than 1%. Nonmalignant meningiomas had LIs of less than 1%, whereas malignant meningiomas had LIs higher than 2.7%. This is an important observation, because malignant meningiomas are not well-defined histopathologically and their growth rate and rate of recurrence cannot be predicted by current diagnostic procedures. By estimating the proliferative potential of individual tumors more precisely, the BUdR LI supplements histopathological diagnosis, allowing a more accurate estimate of pr...Continue Reading

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Citations

Jul 1, 1989·Journal of Neuro-oncology·T HoshinoC B Wilson
Jan 1, 1989·Journal of Cancer Research and Clinical Oncology·M DeckertW Wechsler
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·J MaybaumC E Rogers
May 23, 1991·The New England Journal of Medicine·P M Black
Sep 1, 1990·Cell and Tissue Kinetics·K MatsuokaT Hoshino
May 1, 1988·Journal of Neurosurgery·H P CharmanC B Wilson
Sep 1, 1989·Journal of Neurosurgery·T HoshinoR L Davis
May 1, 2007·Regenerative Medicine·Philippe Taupin
Nov 1, 1989·International Journal of Radiation Biology·J B MitchellE Glatstein
Jan 1, 1994·Cancer Investigation·T J Moynihan, S A Grossman
Mar 1, 1988·Cell and Tissue Kinetics·R SilvestriniP Persici
May 1, 1988·European Journal of Cancer & Clinical Oncology·M DanovaP Paoletti
Jan 1, 1993·British Journal of Neurosurgery·S ChatterjeeR V Jeffreys
Aug 1, 1988·Cancer·K G ChoY Shimosato

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