PMID: 6112296Apr 18, 1981Paper

S100 protein: a marker for human malignant melanomas?

Lancet
R GaynorA Cochran

Abstract

S100 protein is a nervous-system-specific cytoplasmic protein which is also present in human malignant melanoma cell lines. To test for its tumour specificity, biopsy specimens from normal tissue and a wide variety of tumours were tested for S100 by complement fixation and immunofluorescence tests. S100 was present in all of thirteen samples of malignant melanoma tissue and absent from nineteen samples of non-melanocytic tumours, and from normal skin and normal lymph nodes. S100 levels did not correlate with tyrosinase activity in the tissues examined. Detection and measurement of S100 protein may help distinguish poorly differentiated amelanotic malignant melanoma from tumours of obscure histological origin; they may also aid the detection of micrometastatic disease in the lymph nodes and other tissues of melanoma patients.

References

Jun 9, 1965·Biochemical and Biophysical Research Communications·B W Moore
Jun 1, 1970·Journal of Cellular Physiology·S E PfeifferG Sato
Apr 1, 1971·Journal of Neurochemistry·H R HerschmanJ De Vellis
Jun 8, 1972·Brain Research·S E PfeifferL Levine
Jul 1, 1970·The Journal of Investigative Dermatology·A J Cochran
Feb 1, 1970·Journal of Neurochemistry·J E ZuckermanL Levine
Jul 24, 1980·Nature·R GaynorH R Herschman

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Citations

Jan 1, 1984·Archives of Dermatological Research·H YambeK Kikuchi
Oct 1, 1988·European Journal of Pediatrics·M Koskiniemi
Oct 12, 2012·Amino Acids·Nadine TandlerJens Pietzsch
Jun 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H B GuoD Klingmüller
Oct 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H B GuoD Klingmüller
Aug 7, 1999·Journal of the American College of Surgeons·D L Morton, A D Chan
Nov 3, 2005·Nature Clinical Practice. Oncology·Charles R ScogginsKelly M McMasters
May 15, 1998·The British Journal of Dermatology·E S SchultzP Von Den Driesch
Sep 22, 1999·Pathology Oncology Research : POR·T BánfalviS Ottó
Mar 1, 1991·The British Journal of Dermatology·L R Lever, P J Holt
Feb 12, 1998·The British Journal of Dermatology·H D AbrahaR A Sherwood
Dec 1, 1989·Pediatric Dermatology·T K Das GuptaM S Amoss
Apr 1, 1984·Journal of Clinical Pathology·R M MackieM L Turbitt
Dec 1, 1982·Journal of Neurology, Neurosurgery, and Psychiatry·C J SindicP L Masson
Mar 1, 1983·The Journal of Clinical Investigation·F C RamaekersP H Jap
Dec 22, 2012·Future Medicinal Chemistry·Kira G HartmanDavid J Weber
Aug 26, 2004·The British Journal of Dermatology·D L Morton, A J Cochran
Jan 1, 1984·International Journal of Dermatology·H J KahnA Marks
May 1, 1983·Medical Hypotheses·F E Barr
Apr 1, 1985·Pathology·A J Cochran, D R Wen
Jul 26, 2002·Melanoma Research·K StoitchkovT Le Bricon
Jul 1, 1986·Journal of Oral Pathology·G LovasG Rowden
Oct 3, 2006·Biotechnology and Bioengineering·Mario R Melo-JúniorLuiz B Carvalho
Dec 1, 1984·The Anatomical Record·H HachisukaH Nomura
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·J UlrichF Gullotta
Jan 1, 1987·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·P SansoniG De Panfilis
Jan 1, 1983·Histopathology·D I GrahamI Brown
Sep 13, 2012·Expert Review of Proteomics·Cormac W JoyceWilliam M Gallagher
May 10, 2016·PloS One·Małgorzata BajorAleksandra Wysłouch-Cieszyńska
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·A J CochranH R Herschman
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·A J CochranR B Gaynor
Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·G M MaelandsmoO Fodstad

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