S100 protein CP-10 stimulates myeloid cell chemotaxis without activation

Journal of Cellular Physiology
C J CornishC Geczy

Abstract

Leukocyte recruitment to inflammatory foci is generally associated with cellular activation. Recent evidence suggests that chemotactic agents can be divided into two classes, "classical chemoattractants" such as FMLP, C5a, and IL-8, which stimulate directed migration and activation events and "pure chemoattractants" such as TGF-beta 1 which influence actin polymerisation and movement but not oxidative burst and associated granular enzyme release. The studies reported here demonstrate that the murine S100 chemoattractant protein, CP-10, belongs to the "non-classical" group. Despite its potent chemotactic activity for neutrophils and monocytes/macrophages, CP-10 failed to increase [Ca2+]i in human or mouse PMN, although chemotaxis was inhibited by pertussis toxin, confirming the suggestion of a novel Ca(2+)-independent G-protein-coupled pathway for post-receptor signal transduction triggered by "pure chemoattractants." The co-ordinated up-regulation of Mac-1 and down-regulation of L-selectin induced by FMLP on human PMN in vitro was not observed with CP-10. Quantitative changes in immediate (30 s) actin polymerisation occurred with FMLP and CP-10-treated human PMN. The relative F-actin increases induced in WEHI 265 monocytoid cel...Continue Reading

References

Nov 10, 1992·Biochimica Et Biophysica Acta·S W BargerL J Van Eldik
Aug 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J ReibmanG Weissmann
Jan 1, 1991·Cell Motility and the Cytoskeleton·R G WattsT H Howard
Jan 1, 1991·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·A G SembJ Vaage
May 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H SelinfreundL J Van Eldik
Jan 1, 1991·Annual Review of Physiology·J A Cooper
Jun 1, 1990·The Journal of Cell Biology·G P DowneyS Grinstein
Jun 1, 1990·The Journal of Cell Biology·T HowardT Stossel
Oct 1, 1989·Current Opinion in Immunology·T E Hugli
Apr 1, 1984·The Journal of Cell Biology·T H Howard, W H Meyer
Feb 1, 1994·DNA and Cell Biology·S E IismaaC L Geczy
May 21, 1993·Science·T P Stossel
Nov 1, 1993·Trends in Cell Biology·J LeeK Jacobson

❮ Previous
Next ❯

Citations

Mar 10, 2010·Amino Acids·Jesse Goyette, Carolyn L Geczy
Jul 20, 2007·Journal of Molecular Histology·H ZreiqatC L Geczy
May 1, 1997·Journal of Cardiothoracic and Vascular Anesthesia·D Royston
May 10, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pascal RouleauPhilippe A Tessier
Dec 2, 2004·Nature Reviews. Immunology·William Cookson
Oct 6, 2010·Antioxidants & Redox Signaling·Su Yin LimCarolyn L Geczy
Dec 31, 1998·Journal of Cutaneous Pathology·N S McNutt
Aug 26, 2006·Journal of Dental Research·H Y SroussiJ M Palefsky
Jan 29, 2010·Arthritis Research & Therapy·Hala ZreiqatChristopher B Little
Jan 30, 2010·The Journal of Veterinary Medical Science·Tae-Ho ChungCheol-Yong Hwang
Oct 27, 2010·PloS One·Mark C DessingJaklien C Leemans
Jul 28, 2012·Current Molecular Medicine·R DonatoC L Geczy
Dec 21, 2002·Immunological Reviews·William Cookson
Jan 8, 2015·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Michelle Christine NielsenPer Cayé-Thomasen
Mar 17, 2010·The Journal of Allergy and Clinical Immunology·David D TieuRobert P Schleimer
Jan 8, 2004·The Journal of Investigative Dermatology·Michele A GrimbaldestonPrue H Hart
Nov 18, 2008·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Dawn J MazzattiHajo Haase
Jun 15, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·I SalamaJ L Jones
Mar 7, 2006·European Journal of Pharmacology·Rita SelvaticiSusanna Spisani
Sep 17, 2011·Journal of Proteomics·Elena Bonzon-KulichenkoJesús Vázquez
Nov 18, 2014·Growth Factors·Andrew M Scott, Tony Tiganis
Jul 9, 2013·FEMS Microbiology Letters·Douglas A JohnstonGlen E Palmer
Apr 23, 2016·Clinical Therapeutics·Yingjie NieJoost J Oppenheim
Aug 30, 2016·Cellular & Molecular Immunology·Damien Bertheloot, Eicke Latz
Feb 25, 2009·Journal of Leukocyte Biology·Su Yin LimCarolyn L Geczy
Apr 27, 2013·European Journal of Immunology·De YangJoost J Oppenheim
Aug 23, 2019·PloS One·Annabelle CesaroPhilippe A Tessier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alternative Complement Pathway

The Alternative Complement Pathway is part of the innate immune system, and activation generates membrane attack complexes that kill pathogenic cells. Discover the latest research on the Alternative Complement Pathway.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.