S100 protein is a useful and specific marker for hair cells of the lateral line system in postembryonic zebrafish

Neuroscience Letters
A GermanàJosé A Vega

Abstract

The neuromast of the lateral line system of zebrafish has become an ideal model for the study of both developmental genetics and the vertebrate auditory system. Interestingly, the hair cells of this system have been found to selectively display immunoreactivity for S100 protein in some teleosts. In order to provide a selective marker for the sensory cells of the lateral line system, we have analyzed immunohistochemically the expression of S100 protein in zebrafish from the larval to the adult stage. In larval and adult animals S100 protein immunoreactivity was detected restricted to the hair cells of both superficial and canal neuromasts. Apparently the expression of S100 protein by hair cells was independent of the age, but it was expressed heterogeneously in the hair cells of canal neuromasts. The results of this work provide a feasible method to easily identify sensory cells in the neuromasts, and may be of interest in studies regarding development, differentiation or turnover of hair cells.

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Citations

Feb 16, 2008·BMC Evolutionary Biology·Andreas M KraemerSigrun I Korsching
Jul 23, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·F AbbateR Laurà
Aug 16, 2016·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·M LevantiF Abbate
Sep 13, 2019·Anatomia, histologia, embryologia·Francesco AbbateAntonino Germanà
Aug 19, 2020·International Journal of Molecular Sciences·Antonino GermanàFrancesco Abbate
Mar 28, 2018·Anatomia, histologia, embryologia·R LauràM Levanti
Aug 28, 2021·Animals : an Open Access Journal From MDPI·Giuseppe MontalbanoAntonino Germanà

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