PMID: 9538159May 9, 1998Paper

S100 protein serum levels in cutaneous malignant melanoma

Oncology Reports
E SeregniE Bombardieri

Abstract

We investigated the utility of serum S100 determined by means of immunoradiometric assay in a cohort of 438 patients affected by cutaneous melanoma (126 untreated and 312 previously treated). Using 0.2 microg/l cut-off value, determined in 134 healthy blood donors, the sensitivity was 4.2% in stage I patients (4/94), 5.3% in stage II patients (1/19), and 38.5% in stage III patients (5/13). Even though the sensitivity increased progressively from stage I to stage II and III, these differences were not statistically significant. The prognostic significance of S100 evaluation at diagnosis was investigated in terms of survival but no statistical correlation between S100 basal levels and survival was found. In the 312 previously treated patients serum S100 levels were correlated to disease extent, high levels of the marker were observed in 42.8% (9/21) of patients with local recurrence, in 32% (16/50) of patients with lymph node and/or in-transit metastases, in 77.3% (17/22) of patients with distant metastases, and in patients with NED, the specificity of the marker was 96.8% (212/219). The difference between these groups were statistically significant. In conclusion, S100 protein was abnormally high in patients with metastatic mali...Continue Reading

Citations

Jul 29, 2009·Annals of Surgical Oncology·S KruijffH J Hoekstra
Aug 22, 2000·The British Journal of Dermatology·L Brochez, J M Naeyaert
Jun 21, 2002·Clinics in Dermatology·Sarah Brenner, Einat Tamir
May 7, 1999·International Journal of Immunopharmacology·J W Hadden
Aug 28, 2007·Journal of Dermatological Science·A ParadisiR Capizzi
Feb 1, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claus GarbeGernot Rassner
Nov 24, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M DeichmannH Näher

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