S100A10, a novel biomarker in pancreatic ductal adenocarcinoma

Molecular Oncology
Moamen BydounDavid M Waisman

Abstract

Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictive biomarker and a driver of pancreatic tumor growth and invasion. We demonstrated that S100A10 mRNA and protein are overexpressed in human pancreatic tumors compared to normal ducts and nonductal stroma. S100A10 mRNA and methylation status were predictive of overall survival and recurrence-free survival across multiple patient cohorts. S100A10 expression was driven by promoter methylation and the oncogene KRAS. S100A10 knockdown reduced surface plasminogen activation, invasiveness, and in vivo growth of pancreatic cancer cell lines. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer.

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Citations

Mar 5, 2020·Cell Biochemistry and Function·Jin-Tao ZhaoYong Xia
Oct 16, 2019·Pathology International·Yuriko Saiki, Akira Horii
Dec 24, 2018·International Journal of Molecular Sciences·Tannith M NoyeCarmela Ricciardelli
Feb 14, 2021·Journal of Cellular and Molecular Medicine·Hongkai ZhuangBaohua Hou
May 19, 2020·Trends in Pharmacological Sciences·Ji-Seon Seo, Per Svenningsson
Oct 5, 2021·The Journal of International Medical Research·Yu-Lei HouHui Chen

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Methods Mentioned

BETA
surgical resection
profiler
RNA seq
PCR
Assay
pulldown

Software Mentioned

Maplab Wanderer
pyromark Assay Design
graphpad prism
imagej

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