S100A8 and S100A9 mediate endotoxin-induced cardiomyocyte dysfunction via the receptor for advanced glycation end products

Circulation Research
John H BoydKeith R Walley

Abstract

Cardiovascular dysfunction as a result of sepsis is the leading cause of death in the critically ill. Cardiomyocytes respond to infectious pathogens with a Toll-like receptor-initiated proinflammatory response in conjunction with a decrease in contractility, although the downstream events linking Toll-like receptor activation and reduced cardiac contractility remain to be elucidated. Using microarray analysis of cardiac tissue exposed to systemic lipopolysaccharide (LPS), we discovered that 2 small calcium-regulating proteins (S100A8 and S100A9) are highly upregulated. HL-1 cardiomyocytes, isolated primary cardiomyocytes, and live mice were exposed to LPS, whereas beating HL-1 cells had S100A8 and S100A9 overexpressed and their calcium flux quantified. Using in vivo microbubble technology, we delivered S100A8 and S100A9 to normal mouse hearts; using the same technology, we inhibited S100A9 production in mouse hearts and subsequently exposed them to LPS. Coimmunoprecipitation of S100A8 and S100A9 identified interaction with RAGE (the receptor for advanced glycation end products), the cardiac function and postreceptor signaling of which were investigated. HL-1 cardiomyocytes, isolated primary cardiomyocytes, and whole hearts expo...Continue Reading

References

Aug 1, 1995·Journal of Applied Physiology·M J HerbertsonK R Walley
Aug 1, 1995·American Journal of Respiratory and Critical Care Medicine·M J HerbertsonK R Walley
Mar 1, 1994·Journal of Applied Physiology·K R WalleyD J Cooper
Jun 1, 1997·American Journal of Respiratory and Critical Care Medicine·J T GrantonK R Walley
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·W C ClaycombN J Izzo
Dec 9, 1998·The American Journal of Physiology·G S Lynch, J A Faulkner
Aug 13, 1999·The American Journal of Physiology·V VelardeA A Jaffa
Oct 25, 2000·American Journal of Physiology. Heart and Circulatory Physiology·T E McDonaldK R Walley
Nov 22, 2001·Proceedings of the National Academy of Sciences of the United States of America·P MostA Remppis
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Ralica PetrovaHiroshi Yamamoto
Dec 18, 2002·Annals of the New York Academy of Sciences·Hans W M NiessenC Erik Hack
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carle RyckmanPhilippe A Tessier
Mar 29, 2003·Intensive Care Medicine·Mitchell M LevyUNKNOWN International Sepsis Definitions Conference
May 30, 2003·Biochemical Society Transactions·S AkiraK Takeda
Nov 26, 2003·Muscle & Nerve·Dominique Figarella-BrangerJean-François Pellissier
Feb 10, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Steven M WhiteWilliam C Claycomb
Feb 24, 2004·Frontiers in Bioscience : a Journal and Virtual Library·Maria A Brown, W Keith Jones
Apr 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Ehsan Y DavaniKeith R Walley
May 4, 2004·Ultrasound in Medicine & Biology·Raffi BekeredjianRalph V Shohet
Jul 2, 2004·Nature Reviews. Immunology·Shizuo Akira, Kiyoshi Takeda
Sep 1, 2004·Biochemical and Biophysical Research Communications·Ingo MarenholzGünter Fritz
Sep 24, 2004·Immunology·Eva M Pålsson-McDermott, Luke A J O'Neill
Dec 4, 2004·The Journal of Clinical Investigation·Patrick MostWalter J Koch
Jul 12, 2005·Journal of Leukocyte Biology·Vishal C MehraJeffrey R Bender
Jul 23, 2005·Annals of the New York Academy of Sciences·Michiyo KanekoRavichandran Ramasamy
Sep 20, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sven T PlegerPatrick Most
Oct 21, 2005·Journal of Molecular and Cellular Cardiology·S KettlewellG L Smith
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Mar 1, 2006·Circulation·Loredana G BucciarelliRavichandran Ramasamy
Oct 19, 2006·Ultrasound in Medicine & Biology·Grigorios KorosoglouHelmut Kuecherer
Nov 14, 2006·Cardiovascular Research·Oliver J MüllerRaffi Bekeredjian
Jan 24, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B MoserA M Schmidt

❮ Previous
Next ❯

Citations

Jul 16, 2010·Intensive Care Medicine·Benedict C Creagh-BrownAnne Burke-Gaffney
Feb 10, 2012·Basic Research in Cardiology·H Christian VolzMartin Andrassy
Mar 10, 2010·Amino Acids·Jesse Goyette, Carolyn L Geczy
Mar 27, 2012·Journal of Thrombosis and Thrombolysis·Amit N VoraDavid A Morrow
Mar 30, 2012·Current Heart Failure Reports·Ravichandran Ramasamy, Ann Marie Schmidt
Sep 4, 2012·Current Infectious Disease Reports·Maria Cristina Vazquez GuillametAndrew J Patterson
Jul 21, 2010·Journal of Cardiovascular Translational Research·David RohdePatrick Most
Jul 31, 2013·Veterinary Immunology and Immunopathology·Mirja KoyHans-Joachim Schuberth
Jun 24, 2010·Molecular Therapy : the Journal of the American Society of Gene Therapy·Dongmei SunHuang-Ge Zhang
May 9, 2009·Nature Medicine·Peter A Ward
Oct 6, 2010·Antioxidants & Redox Signaling·Su Yin LimCarolyn L Geczy
Jun 8, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Li JianhuiLucas Liaudet
Jul 31, 2010·Cardiovascular Psychiatry and Neurology·Estelle LeclercStefan W Vetter
Jul 21, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Fei Song, Ann Marie Schmidt
Dec 7, 2011·Circulation·Koichi ShimizuKevin Croce
Sep 24, 2013·Critical Care : the Official Journal of the Critical Care Forum·James J Douglas, Keith R Walley
Aug 6, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Sumeet MathurJohn H Boyd
Jul 28, 2012·Current Molecular Medicine·R DonatoC L Geczy
May 19, 2011·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Bahig M ShehataCarlos S Moreno
Apr 11, 2012·International Journal of Molecular Sciences·Thomas VoglLudmilla A Morozova-Roche
Feb 25, 2014·Cytokine & Growth Factor Reviews·Peter KruzliakGeorge J Fodor
Apr 3, 2014·The Journal of Clinical Investigation·Yunmei WangDaniel I Simon
May 16, 2013·Cellular and Molecular Life Sciences : CMLS·Koen Van CrombruggenClaus Bachert
Oct 3, 2014·Mediators of Inflammation·Rosana Lima PaganoRenata Giorgi
Oct 17, 2014·Science Translational Medicine·Keith R WalleyJohn H Boyd
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Dong XuYong-Qing Yang
Dec 5, 2014·Scandinavian Journal of Clinical and Laboratory Investigation·Pelin OktayogluKemal Nas
Aug 21, 2014·Systems Biology in Reproductive Medicine·Francesco GiannessiRiccardo Ruffoli
Apr 9, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Xiao-Li WangHon-Chi Lee
Dec 20, 2015·Current Opinion in Immunology·H N StephensonA Zychlinsky
Sep 16, 2011·The Journal of Allergy and Clinical Immunology·Eleni TsitsiouMark A Lindsay
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Keith R Walley
Jan 26, 2010·Biochemical Pharmacology·Shi Fang YanAnn Marie Schmidt
Jun 23, 2009·Journal of Molecular and Cellular Cardiology·Carolin KrausPatrick Most

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Calcium & Bioenergetics

Bioenergetic processes, including cellular respiration and photosynthesis, concern the transformation of energy by cells. Here is the latest research on the role of calcium in bioenergetics.