S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis.

The Journal of Clinical Investigation
Ninecia R ScottShabaana A Khader

Abstract

Neutrophil accumulation is associated with lung pathology during active tuberculosis (ATB). However, the molecular mechanism or mechanisms by which neutrophils accumulate in the lung and contribute to TB immunopathology are not fully delineated. Using the well-established mouse model of TB, our new data provide evidence that the alarmin S100A8/A9 mediates neutrophil accumulation during progression to chronic TB. Depletion of neutrophils or S100A8/A9 deficiency resulted in improved Mycobacterium tuberculosis (Mtb) control during chronic but not acute TB. Mechanistically, we demonstrate that, following Mtb infection, S100A8/A9 expression is required for upregulation of the integrin molecule CD11b specifically on neutrophils, mediating their accumulation during chronic TB disease. These findings are further substantiated by increased expression of S100A8 and S100A9 mRNA in whole blood in human TB progressors when compared with nonprogressors and rapidly decreased S100A8/A9 protein levels in the serum upon TB treatment. Furthermore, we demonstrate that S100A8/A9 serum levels along with chemokines are useful in distinguishing between ATB and asymptomatic Mtb-infected latent individuals. Thus, our results support targeting S100A8/A9 ...Continue Reading

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Citations

Jul 12, 2020·The FEBS Journal·Stefan H OehlersKristina M Cook
Jun 17, 2020·Frontiers in Immunology·Caleb N Muefong, Jayne S Sutherland
Sep 18, 2020·The Journal of Infectious Diseases·Joana VitteJean-Louis Mege
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Methods Mentioned

BETA
bronchoalveolar lavage
PCR
reverse
RNA-Seq
flow cytometry
FCS
light microscopy
ELISA

Software Mentioned

FlowJo
Visiopharm
FACS Sortware
Visiomorph
GraphPad Prism
Bio
Plex
SAS

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