S100A9-Targeted Cowpea Mosaic Virus as a Prophylactic and Therapeutic Immunotherapy against Metastatic Breast Cancer and Melanoma.

Advanced Science
Young Hun ChungNicole F Steinmetz

Abstract

Prognosis and treatment of metastatic cancer continues to be one of the most difficult and challenging areas of oncology. Treatment usually consists of chemotherapeutics, which may be ineffective due to drug resistance, adverse effects, and dose-limiting toxicity. Therefore, novel approaches such as immunotherapy have been investigated to improve patient outcomes and minimize side effects. S100A9 is a calcium-binding protein implicated in tumor metastasis, progression, and aggressiveness that modulates the tumor microenvironment into an immunosuppressive state. S100A9 is expressed in and secreted by immune cells in the pre-metastatic niche, as well as, post-tumor development, therefore making it a suitable targeted for prophylaxis and therapy. In previous work, it is demonstrated that cowpea mosaic virus (CPMV) acts as an adjuvant when administered intratumorally. Here, it is demonstrated that systemically administered, S100A9-targeted CPMV homes to the lungs leading to recruitment of innate immune cells. This approach is efficacious both prophylactically and therapeutically against lung metastasis from melanoma and breast cancer. The current research will facilitate and accelerate the development of next-generation targeted im...Continue Reading

References

Jul 27, 2000·Current Opinion in Pulmonary Medicine·K Y YonedaD K Shelton
Apr 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H HochreinM O'Keeffe
Nov 15, 2002·Chemical Communications : Chem Comm·Eric GillitzerTrevor Douglas
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Carle RyckmanPhilippe A Tessier
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Alexander HermaniDoris Mayer
Jul 19, 2006·Biochemical Pharmacology·Christoffer GebhardtJochen Hess
Nov 9, 2006·Experimental Lung Research·Markus O HenkeJa Seok Koo
May 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pratik SinghMarianne Manchester
Jan 1, 2008·The Oncologist·Christian WidakowichAhmad Awada
Apr 24, 2008·Chemistry : a European Journal·Adeline MiermontXuefei Huang
Sep 30, 2008·Nature Cell Biology·Sachie HiratsukaYoshiro Maru
Aug 12, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Julia NémethJochen Hess
Jun 5, 2010·Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry·Kenneth HsuMark C Herzberg
Jan 14, 2011·Molecular Cancer Research : MCR·Mie IchikawaGeetha Srikrishna
Sep 14, 2011·Journal of Innate Immunity·Geetha Srikrishna
Apr 4, 2012·PloS One·Eva KällbergTomas Leanderson
Jul 26, 2012·Molecular Pharmaceutics·Alaa A A AljabaliDavid J Evans
Nov 6, 2012·Biochimica Et Biophysica Acta·Joseph Markowitz, William E Carson
Dec 29, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lisa A RidnourDavid A Wink
Sep 21, 2013·American Journal of Respiratory and Critical Care Medicine·Radha GopalShabaana A Khader
Apr 4, 2015·Science·Ton N Schumacher, Robert D Schreiber
Feb 3, 2016·F1000Research·Martin L AshdownBrendon J Coventry
Dec 6, 2017·Scientific Reports·Peter BankheadPeter W Hamilton
Apr 4, 2018·Molecular Pharmaceutics·P Jack HoopesSteven N Fiering
Apr 11, 2018·Oncoimmunology·C Bryce Johnson, Shwe Y Win
May 26, 2018·Molecular Pharmaceutics·Abner A MurrayNicole F Steinmetz
Jun 21, 2018·ImmunoTargets and Therapy·Beatriz DominguesHelena Pópulo
Jun 27, 2018·Frontiers in Immunology·Siwen WangJian Ma
Oct 18, 2018·Cancer Medicine·Matias RiihimäkiKari Hemminki
Nov 2, 2018·Biophysics Reviews·Anne R Bresnick
Dec 24, 2018·Expert Opinion on Investigational Drugs·Bartosz SzostakAndrzej Pawlik

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.