[S100B level and cognitive dysfunction after robotic-assisted laparoscopic radical prostatectomy procedures: a prospective observational study].

Revista brasileira de anestesiologia
Nilgun Kavrut OzturkMurat Savas

Abstract

The present study investigated the association between Postoperative Cognitive Dysfunction (POCD) and increased serum S100B level after Robotic-Assisted Laparoscopic Radical Prostatectomy (RALRP). The study included 82 consecutive patients who underwent RALRP. Serum S100B levels were determined preoperatively, after anesthesia induction, and at 30 minutes and 24 hours postoperatively. Cognitive function was assessed using neuropsychological testing preoperatively and at 7 days and 3 months postoperatively. Twenty-four patients (29%) exhibited POCD 7 days after surgery, and 9 (11%) at 3 months after surgery. Serum S100B levels were significantly increased at postoperative 30minutes and 24 hours in patients displaying POCD at postoperative 7 days (p = 0.0001 for both) and 3 months (p = 0.001 for both) compared to patients without POCD. Duration of anesthesia was also significantly longer in patients with POCD at 7 days and 3 months after surgery compared with patients without POCD (p = 0.012, p = 0.001, respectively), as was duration of Trendelenburg (p = 0.025, p = 0.002, respectively). Composite Z score in tests performed on day 7 were significantly correlated with duration of Trendelenburg and duration of anesthesia (p = 0.000...Continue Reading

Associated Clinical Trials

References

May 1, 1995·The Annals of Thoracic Surgery·J M MurkinJ A Blumenthal
Feb 24, 2001·Acta Anaesthesiologica Scandinavica·L S RasmussenUNKNOWN ISPOCD group. The International Study of Postoperative Cognitive Dysfunction
Aug 10, 2002·Anesthesiology·Tim JohnsonUNKNOWN ISPOCD2 Investigators
Nov 18, 2003·Acta Anaesthesiologica Scandinavica·J CanetUNKNOWN ISPOCD2 investigators
Mar 11, 2004·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Tom N Tombaugh
Jan 11, 2005·British Journal of Anaesthesia·C D Hanning
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Denise RohanDenis C Moriarty
Dec 1, 2006·The Journal of International Medical Research·J R LeeS H Han
Dec 25, 2007·Anesthesiology·Terri G MonkJoachim S Gravenstein
May 6, 2008·Clinical Biochemistry·Carlos-Alberto GonçalvesPatrícia Nardin
Jul 31, 2012·European Urology·Francesco PorpigliaCristian Fiori
Sep 19, 2012·Journal of Clinical Anesthesia·Hamdy AwadJerome O'Hara
Jul 30, 2015·Journal of the International Neuropsychological Society : JINS·Katherine A GiffordUNKNOWN Alzheimer’s Disease Neuroimaging Initiative

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Citations

Dec 7, 2020·Revista brasileira de anestesiologia·André P Schmidt, Maria José C Carmona

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