S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.

The American Journal of Pathology
Kate LinesTatjana Crnogorac-Jurcevic

Abstract

Several S100 proteins are up-regulated in pancreatic ductal adenocarcinoma (PDAC), the most significant being S100P. We previously reported on S100PBP, a binding partner of S100P, that shows no homology to any described protein and whose functions are completely unknown. To determine S100PBP expression across human tissues and organs, immunohistochemistry was performed using both multiorgan- and in-house-constructed pancreatic tissue microarrays. To establish S100PBP functions, cell lines with either stably overexpressed or silenced S100PBP were generated and investigated using Affymetrix gene expression arrays and complementary functional assays. We show that S100PBP is differentially expressed in various healthy and tumor specimens, which is both cancer- and tissue-type dependent. In healthy pancreas, S100PBP is expressed in the nuclear/perinuclear region of both exocrine and endocrine compartments. In early precancerous lesions, S100PBP is translocated to the cytoplasm, whereas in PDAC and metastatic lesions, its expression is significantly diminished. The most pronounced phenotypic change after manipulation of S100PBP expression was seen in adhesion; this was significantly reduced after S100PBP up-regulation and increased a...Continue Reading

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Citations

Oct 19, 2012·Radiology and Oncology·Tjasa VizinJanko Kos
Dec 3, 2014·Pathology, Research and Practice·Doerthe JechorekSabine Franke
Aug 27, 2014·International Journal of Cancer. Journal International Du Cancer·Hong XieWeng-Onn Lui
Feb 7, 2018·Current Pharmacology Reports·Amanda R MuñozAddanki P Kumar

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