PMID: 8965652Mar 1, 1996Paper

S103L reactive chondroitin sulfate proteoglycan (aggrecan) mRNA expressed in developing chick brain and cartilage is encoded by a single gene

Brain Research. Molecular Brain Research
H LiN B Schwartz

Abstract

A large chondroitin sulfate proteoglycan (CSPG) identified in embryonic chick brain, and synthesized exclusively by neurons in a developmentally expressed pattern that coincides with migration and establishment of neuronal nuclei, reacts with a monoclonal antibody (S103L) developed against the cartilage-specific CSPG, aggrecan. The relationship of the brain and cartilage S103L CSPGs was established by chemical, biosynthetic and molecular analyses. Significant posttranslational differences (absence of keratan sulfate (KS), less CS, and different sulfation patterns) distinguish the brain S103L species from the cartilage S103L species. However, quantitative and qualitative Northern analysis, cassette RT-PCR and direct cloning and sequencing of the entire brain-specific S103L CSPG coding sequence, all indicate that the brain and cartilage core proteins are identical. Thus, although the S103L CSPG synthesized by chick brain and cartilage are the product of a single gene, they are clearly biochemically distinct and differentially expressed proteoglycan products, suggesting tissue specific roles for these proteoglycan homologs.

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Citations

Oct 15, 2013·Acta Biomaterialia·Tobias MillerJohnna S Temenoff
Jul 12, 2003·Brain Research. Developmental Brain Research·Miriam S DomowiczNancy B Schwartz
May 25, 1999·Progress in Neurobiology·R Probstmeier, P Pesheva
Sep 9, 2000·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M DomowiczN B Schwartz
Apr 15, 2003·Molecular and Cellular Neurosciences·Jaimie F BorisoffWolfram Tetzlaff
Jun 4, 2002·Glycobiology·Nancy B Schwartz, Miriam Domowicz
Aug 31, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Betty P LiuStephen M Strittmatter
Apr 29, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chin Lik TanJames W Fawcett
Sep 28, 2001·Biochemical and Biophysical Research Communications·R T Yan, S Z Wang
Dec 23, 2008·Biomedical Chromatography : BMC·Efstathios A SinourisNickoletta Papageorgakopoulou
Jan 22, 2008·Developmental Biology·Miriam S DomowiczNancy B Schwartz
Oct 27, 2006·Developmental Biology·Elaine L Shelton, Katherine E Yutzey
Aug 2, 2015·Brain Research·Joel Levine
Oct 9, 2012·Brain, Behavior, and Immunity·Star W LeeTheo D Palmer
Jun 23, 1998·The Journal of Biological Chemistry·M SchmalfeldtD R Zimmermann
Jul 29, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Maj S ThomsenTorben Moos
Jan 1, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Miriam S DomowiczNancy B Schwartz
Apr 10, 1999·The Journal of Biological Chemistry·R MiuraY Yamaguchi
Oct 4, 2000·Physiological Reviews·C E Bandtlow, D R Zimmermann

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