S1P3 receptors mediate the potent constriction of cerebral arteries by sphingosine-1-phosphate

European Journal of Pharmacology
Salvatore SalomoneChristian Waeber

Abstract

We characterized the effect of Sphingosine-1-phosphate (S1P) on vascular tone. S1P selectively constricted isolated cerebral, but not peripheral arteries, despite ubiquitous expression of S1P(1), S1P(2), S1P(3) and S1P(5) receptor mRNA. Clostridium B and C3 toxins and the rho-kinase inhibitor Y27632 (trans-N-(4-pyridyl)-4-(l-aminoethyl)-cyclohexane carboxamide) reduced this vasoconstriction to S1P, indicating that the response was mediated through Rho. Pertussis toxin displayed only weak inhibition, suggesting minor involvement of G(i/o) protein. The S1P effect was specifically reduced by adenovirus bearing a s1p(3) but not s1p(2), antisense construct. Furthermore, suramin, which selectively blocks S1P(3) receptors, inhibited the vasoconstrictor effect of S1P, indicating that S1P(3) receptors account for at least part of S1P-mediated vasoconstriction in cerebral arteries. In vivo, intracarotid injection of S1P decreased cerebral blood flow, an effect prevented by suramin treatment. Because S1P constricts cerebral blood vessels and is released from platelets during clotting, the S1P/S1P(3) system constitutes a novel potential target for cerebrovascular disease therapy.

References

Mar 1, 1986·Neurology·J Bogousslavsky, F Regli
Aug 21, 1995·FEBS Letters·C UllmerH Lübbert
Feb 15, 1993·Biochemical and Biophysical Research Communications·H OkazakiY Takuwa
May 1, 1993·The Biochemical Journal·T EichholtzW H Moolenaar
Nov 1, 1996·Journal of Virology·N MitterederB C Trapnell
Aug 24, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·W D DietrichB D Watson
Dec 22, 1999·Trends in Pharmacological Sciences·K R Lynch, D S Im
May 9, 2000·The Journal of Biological Chemistry·D S ImK R Lynch
Jun 22, 2000·Analytical Biochemistry·N MurataF Okajima
Aug 6, 2000·Circulation Research·A GohlaS Offermanns
Oct 29, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D EnglishJ G Garcia
Nov 23, 2000·British Journal of Pharmacology·E Spitzbarth-RégrignyC Capdeville-Atkinson
May 31, 2002·Pharmacological Reviews·Jerold ChunGabor Tigyi

❮ Previous
Next ❯

Citations

Mar 30, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Denise G Hemmings
Feb 24, 2009·Cardiovascular Research·Junsuke Igarashi, Thomas Michel
Jan 29, 2011·American Journal of Physiology. Cell Physiology·Kristen Park HopsonChristian Waeber
May 4, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·William S SzczepaniakBryan J McVerry
Jul 5, 2008·Circulation Research·Naoki SawadaJames K Liao
Feb 18, 2004·The Journal of Clinical Investigation·Jerzy-Roch NoferBodo Levkau
Feb 19, 2015·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·S H RheeM E DiSanto
Nov 19, 2013·Biochimica Et Biophysica Acta·Marc BigaudVolker Brinkmann
Feb 18, 2011·The Journal of Sexual Medicine·Xin-Hua ZhangMichael E Disanto
Sep 5, 2009·The American Journal of Pathology·Changyong LiLiying Li
Sep 6, 2008·Journal of Cellular Biochemistry·Magdalena Birker-RobaczewskaOliver Nayler
Mar 30, 2007·Acta Paediatrica. Supplement·Martin C MichelStephan L M Peters
Apr 27, 2011·Annals of Neurology·Jeffrey A Cohen, Jerold Chun
Aug 8, 2006·Biochimica Et Biophysica Acta·Chiara Donati, Paola Bruni
Jan 13, 2006·Trends in Molecular Medicine·Shannon E GardellJerold Chun
Oct 27, 2004·British Journal of Pharmacology·Astrid E AlewijnseMartin C Michel
Feb 12, 2011·British Journal of Pharmacology·Mirjam SchuchardtMarkus van der Giet
Apr 19, 2008·European Journal of Pharmacology·Astrid E Alewijnse, Stephan L M Peters
Mar 4, 2009·American Journal of Obstetrics and Gynecology·Katherine S SandhuMichael E Disanto
Mar 24, 2012·Allergology International : Official Journal of the Japanese Society of Allergology·Yasushi MakinoKaichiro Kamiya
Apr 7, 2015·Revista Portuguesa De Cardiologia : Orgão Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology·Carlos AguiarRicardo Pacheco
Sep 18, 2012·Cell Metabolism·Timothy Hla, Andrew J Dannenberg
Dec 3, 2014·American Heart Journal·John CammVolker Brinkmann
Aug 6, 2008·Journal of Pharmacological Sciences·Ryoichi TanakaYuji Imaizumi
Jun 19, 2016·The Journal of Pharmacology and Experimental Therapeutics·Anna Cantalupo, Annarita Di Lorenzo
Sep 29, 2009·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mariangela ChisariSalvatore Salomone
Nov 23, 2006·Journal of Receptor and Signal Transduction Research·Sandra Siehler, Danilo Guerini
Nov 5, 2016·Annual Review of Physiology·Keisuke Yanagida, Timothy Hla
Nov 30, 2004·Cellular Signalling·Kenneth R WattersonSarah Spiegel
Apr 15, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Anthony PilorgetRichard Béliveau
Aug 19, 2007·Journal of Lipid Research·Kelley M Argraves, W Scott Argraves
Nov 17, 2004·Circulation·Bodo LevkauMichael Schäfers
Jul 1, 2006·Stroke; a Journal of Cerebral Circulation·Sophocles Chrissobolis, Christopher G Sobey

❮ Previous
Next ❯

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