Saccade movements effect on the intravitreal drug delivery in vitreous substitutes: a numerical study

Biomechanics and Modeling in Mechanobiology
Amirreza ModareszadehGoodarz Ahmadi

Abstract

In this study, the distributions of intravitreal injected drugs in post-vitrectomy human eyes, which are subjected to periodic saccade movements, are investigated. The computational model for the vitreous cavity of human eye is a sphere with one side truncated by the eye lens. A dynamic mesh technique was used to model the eye motion and the unsteady 3-D forms of continuity; Navier-Stokes and concentration transport of drug equations were solved numerically. The numerical model was validated earlier for the vitreous liquid flow field. The predicted drug concentration for idealized geometry was compared with the available analytic solution and excellent agreement was observed. The validated computer model was then used to simulate a real vitreous cavity filled with Balanced Salt Solution or aqueous humor as a vitreous substitute in order to obtain distribution of drugs in the post-vitrectomy eyes or liquefied vitreous. Additionally, effects of locations of drug injection, drug diffusion coefficients and saccade amplitude on the drug distribution and its uniformity were investigated. Although the earlier findings in the literature reported a day or a week as a needed time for drug uniform distribution in the vitreous substitutes,...Continue Reading

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Citations

May 29, 2014·Physiology & Behavior·SeyedAmirreza ModarreszadehGoodarz Ahmadi
Apr 28, 2016·Mathematical Medicine and Biology : a Journal of the IMA·Hamidreza Hajiani BoushehrianGoodarz Ahmadi
Aug 9, 2018·Annals of Biomedical Engineering·Marco FerroniFederica Boschetti
May 24, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sahar AwwadSteve Brocchini
Aug 2, 2019·Ocular Oncology and Pathology·Michael D YuCarol L Shields

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