Saccadic Eye Movements and Attentional Control in Alzheimer's Disease

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
Nicolas NoiretPierre Vandel

Abstract

Several studies have demonstrated saccadic eye movement (SEM) abnormalities in Alzheimer's disease (AD) when patients performed prosaccade (PS) and antisaccade (AS) tasks. Some studies have also showed that SEM abnormalities were correlated with dementia rating tests such as the Mini Mental State Evaluation (MMSE). Therefore, it has been suggested that SEMs could provide useful information for diagnosis. However, little is known about predictive saccades (PreS)-saccades triggered before or very quickly after stimuli appearance-and their relationships with cognition in AD. Here, we aimed to examine the relationships between our usual dementia screening tests and SEM parameters in PS, AS, and also PreS task. We compared SEMs in 20 patients suffering from AD and in 35 healthy older adults (OA) in PS, AS, and PreS task. All participants also completed a neuropsychological evaluation. We showed that AD patients had higher latency and latency variability regardless the tasks, and also higher AS cost, in comparison with OA. Moreover, AD patients made more uncorrected AS and took more time-to-correct incorrect AS. In PreS task, AD patients showed higher gain and gain variability than OA when they made anticipated saccades. Close relati...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Jun 1, 1992·Brain : a Journal of Neurology·R ParasuramanC L Grady
Jun 1, 1988·Neurology·E GroberR Dresner
Jan 1, 1987·Vision Research·A M Bronstein, C Kennard
Oct 1, 1986·Annals of Neurology·W A Fletcher, J A Sharpe
Oct 1, 1973·The British Journal of Psychiatry : the Journal of Mental Science·B Isaacs, A T Kennie
Sep 1, 1983·Archives of Neurology·L A HersheyD Grossniklaus
Feb 1, 1995·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·F W BylsmaJ Brandt
Dec 1, 1996·Journal of Personality Assessment·A T BeckW Ranieri
Feb 5, 1999·Neurology·H BuschkeR B Lipton
Apr 23, 1999·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·F ColletteE Salmon
May 26, 1999·Vision Research·J J Clark
Jan 5, 2002·Journal of the American Academy of Child and Adolescent Psychiatry·S H MostofskyD S Zee
Sep 17, 2003·Archives of Neurology·Ruxsana Shafiq-AntonacciJon Currie
Feb 21, 2004·Nature Reviews. Neuroscience·Douglas P Munoz, Stefan Everling
Apr 20, 2004·Current Opinion in Neurology·Charles Pierrot-DeseillignyRené M Müri
Aug 5, 2004·Neuropsychology·Elise J LevinoffHoward Chertkow
Apr 14, 2005·Annals of the New York Academy of Sciences·Ch Pierrot-DeseillignyD Milea
Apr 30, 2005·Biological Psychiatry·Trevor J CrawfordSue Tetley
Aug 30, 2005·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Sophie BaudicLatchezar Traykov
Mar 10, 2006·Vision Research·Jay PrattRichard A Abrams
Jun 10, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam L BoxerStephen G Lisberger
Apr 5, 2007·Nature Protocols·Christopher R Bowie, Philip D Harvey
Mar 26, 2008·Brain : a Journal of Neurology·Siobhan GarbuttAdam L Boxer
Nov 26, 2008·Brain and Cognition·S B Hutton
Feb 17, 2010·Journal of Alzheimer's Disease : JAD·Liam D KaufmanSandra E Black
Jan 18, 2011·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Cheryl L StopfordJulie S Snowden
May 11, 2012·Brain and Behavior·Liam D KaufmanSandra E Black
Aug 30, 2013·Neurology·Hilary W HeuerAdam L Boxer
Sep 4, 2014·Journal of Alzheimer's Disease : JAD·Robert J MolitorBrandon A Ally
Jul 15, 2015·Progress in Neurobiology·Kelsey ClarkBehrad Noudoost

❮ Previous
Next ❯

Citations

Mar 4, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ling TaoLi Feng
Jun 12, 2018·Computational and Mathematical Methods in Medicine·Jessica BeltránJean-François Dartigues
Apr 7, 2020·Journal of Alzheimer's Disease : JAD·Marta Luísa Gonçalves de Freitas PereiraOrestes Vicente Forlenza
Jan 20, 2019·Aging Clinical and Experimental Research·Negin ChehrehnegarMahshid Foroughan
May 1, 2021·Aging & Mental Health·Negin ChehrehnegarMahshid Foroughan
Jul 17, 2021·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Megan Polden, Trevor J Crawford

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition
Nicolas NoiretEric Laurent
© 2022 Meta ULC. All rights reserved