PMID: 11321613Apr 26, 2001Paper

Saccadic hypometria in drug-naive and drug-treated schizophrenic patients: a working memory deficit?

Psychophysiology
S B HuttonE M Joyce

Abstract

In certain conditions patients with schizophrenia make markedly smaller (hypometric) saccades than controls. This hypometria has been thought to reflect dopaminergic blockade as a result of antipsychotic medication. We tested this hypothesis by comparing the performance of an antipsychotic-naïve group and an antipsychotic-treated group of first-episode schizophrenic patients on a predictive saccade paradigm. We explored the possibility that hypometria reflects a spatial working memory deficit by correlating performance on neuropsychological tests of mnemonic function with saccadic accuracy. Both the drug-naïve and treated schizophrenic patients made hypometric saccades when compared with a group of matched controls. Primary saccade amplitude also correlated significantly with performance on some of the neuropsychological tests. These results are discussed in terms of the roles of cortical dopamine and working memory deficits in schizophrenic patients.

Citations

Sep 29, 2007·European Archives of Psychiatry and Clinical Neuroscience·Uta SailerAndreas Straube
Apr 22, 2004·Schizophrenia Research·Susan R McGurkRobert Kern
Feb 27, 2004·Schizophrenia Research·Deana B DavalosRandal G Ross
Jun 10, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Margret S H HarrisJohn A Sweeney
Sep 5, 2002·Neuropsychologia·T L HodgsonC Kennard
Nov 26, 2015·Neuroscience Research·Jun IzawaHiroshi Imamizu
Nov 26, 2008·Brain and Cognition·S B Hutton
Jan 18, 2007·European Psychiatry : the Journal of the Association of European Psychiatrists·Marie-Noëlle LevauxEmmanuel Stip
Jun 25, 2013·Psychophysiology·Julia BenderNorbert Kathmann
May 20, 2017·Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists·Nicolas NoiretPierre Vandel
Aug 28, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ulrich EttingerTonmoy Sharma
Jul 19, 2019·Schizophrenia Bulletin·Steven J LuckJames M Gold

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