Saccharide modified pharmaceutical nanocarriers for targeted drug and gene delivery

Current Pharmaceutical Design
Wangyang YuChangjun Li

Abstract

Nanocarriers are effective non-viral vectors for drug and gene delivery with low immunogenicity in comparison with viral vectors. However, the lack of organ or cell specificity sometimes hinders their application and brings about unexpected side effects. Active targeting is an outstanding strategy recently developed for drug delivery systems, for example, surface modification of nanocarriers with specific ligands could target the pathological area to provide the maximum therapeutic efficacy. In such cases, the characteristics of the ligands determine the active targeting abilities of the nanocarrier systems. Recently, more attentions have been paid to saccharides as ligands for saccharide-modified nanocarriers, possesing the receptor-mediated targeting properties and showing the potential for cell-specific delivery of drugs and genes. In this review, various kinds of glycosylated nanocarriers are discussed, including: varying ligands, targeting properties, therapeutic effects, and methods for administering the nanocarriers. The advantages as well as the probable associated drawbacks of these vectors are communicated.

Citations

Mar 7, 2012·International Journal of Nanomedicine·Fansheng KongYong Wang
May 24, 2012·International Journal of Nanomedicine·Zhaoshun JiangFansheng Kong
Sep 29, 2011·Journal of Drug Targeting·Giuseppe TrapaniValentino Laquintana
Jun 30, 2015·Expert Opinion on Drug Delivery·Jun-Ichiro Jo, Yasuhiko Tabata
Jun 23, 2015·Expert Opinion on Drug Delivery·Hidetoshi ArimaKeiichi Motoyama
May 23, 2015·Drug Discoveries & Therapeutics·Yan Zhang, Fengshan Wang
Jun 10, 2011·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Mingrong ChengRunjiao Zhou
Mar 19, 2014·Drug Discovery Today·Xingwang Zhang, Wei Wu
May 15, 2015·Organic & Biomolecular Chemistry·Kevin BuffetStéphane P Vincent
Nov 11, 2014·Chemical Communications : Chem Comm·Sun-Jung KimBong Hyun Chung

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