Saccharomyces cerevisiae Boulardii Reduces the Deoxynivalenol-Induced Alteration of the Intestinal Transcriptome

Toxins
Imourana Alassane-KpembiIsabelle P Oswald

Abstract

Type B trichothecene mycotoxin deoxynivalenol (DON) is one of the most frequently occurring food contaminants. By inducing trans-activation of a number of pro-inflammatory cytokines and increasing the stability of their mRNA, trichothecene can impair intestinal health. Several yeast products, especially Saccharomyces cerevisiae, have the potential for improving the enteric health of piglets, but little is known about the mechanisms by which the administration of yeast counteracts the DON-induced intestinal alterations. Using a pig jejunum explant model, a whole-transcriptome analysis was performed to decipher the early response of the small intestine to the deleterious effects of DON after administration of S. cerevisiae boulardii strain CNCM I-1079. Compared to the control condition, no differentially expressed gene (DE) was observed after treatment by yeast only. By contrast, 3619 probes-corresponding to 2771 genes-were differentially expressed following exposure to DON, and 32 signaling pathways were identified from the IPA software functional analysis of the set of DE genes. When the intestinal explants were treated with S. cerevisiae boulardii prior to DON exposure, the number of DE genes decreased by half (1718 probes cor...Continue Reading

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Citations

Mar 16, 2019·Toxins·Imourana Alassane-KpembiIsabelle P Oswald
Dec 17, 2020·Comprehensive Reviews in Food Science and Food Safety·Hongyan GuoXiulan Sun
Mar 8, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Imourana Alassane-KpembiIsabelle P Oswald
Nov 6, 2020·Asian-Australasian Journal of Animal Sciences·Debora Muratori Holanda, Sung Woo Kim

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Datasets Mentioned

BETA
GPL16524

Methods Mentioned

BETA
nuclear translocation
biopsy
electrophoresis
Feature Extraction

Software Mentioned

REST©
R Bioconductor
Agilent Feature Extraction
Agilent Scan Control
limma
Primer Express
Ingenuity Pathway Analysis ( IPA )
IPA
R
Bioconductor

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