Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway

Molecular Microbiology
Eve LenssenM A Collart

Abstract

The Ccr4-Not complex is a global regulator of transcription that affects genes positively and negatively and is thought to modulate the activity of TFIID. In the present work, we provide evidence that the Ccr4-Not complex may contribute to transcriptional regulation by the Ras/cAMP pathway. Several observations support this model. First, Msn2/4p-dependent transcription, which is known to be under negative control of cAMP-dependent protein kinase (PKA), is derepressed in all ccr4-not mutants. This phenotype is paralleled by specific post-translational modification defects of Msn2p in ccr4-not mutants relative to wild-type cells. Secondly, mutations in various NOT genes result in a synthetic temperature-sensitive growth defect when combined with mutations that compromise cells for PKA activity and at least partially suppress the effects of both a dominant-active RAS2Val-19 allele and loss of Rim15p. Thirdly, Not3p and Not5p, which are modified and subsequently degraded by stress signals that also lead to increased Msn2/4p-dependent activity, show a specific two-hybrid interaction with Tpk2p. Together, our results suggest that the Ccr4-Not complex may function as an effector of the Ras/cAMP pathway that contributes to repress basa...Continue Reading

References

Sep 1, 1991·Molecular and Cellular Biology·P A Kolodziej, R A Young
Nov 1, 1987·Genes & Development·J NikawaM Wigler
May 1, 1986·Journal of Bacteriology·K Tatchell
Sep 1, 1995·Microbiological Reviews·W H Mager, A J De Kruijff
Jun 1, 1993·Microbiological Reviews·M Werner-WashburneR A Singer
Nov 1, 1995·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Ruis, C Schüller
Apr 26, 1996·The Journal of Biological Chemistry·I MailletJ Labarre
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·A P Schmitt, K McEntee
Aug 26, 1998·The Journal of Biological Chemistry·C GodonJ Labarre
Dec 9, 1998·Cell·F C HolstegeR A Young
Oct 12, 2000·Journal of Molecular Biology·L MailletM A Collart
Dec 5, 2000·Molecular Biology of the Cell·A P GaschP O Brown
Feb 17, 2001·Molecular Biology of the Cell·H C CaustonR A Young
Jun 19, 2001·Nucleic Acids Research·M C DaugeronB Séraphin

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Citations

Dec 25, 2008·The Journal of Microbiology·Joakim Norbeck
Sep 25, 2010·Omics : a Journal of Integrative Biology·Luciano GaldieriAles Vancura
Mar 30, 2007·Nucleic Acids Research·Klaas W MulderH Th Marc Timmers
Oct 30, 2007·Eukaryotic Cell·Eve LenssenMartine A Collart
Oct 22, 2005·Infection and Immunity·Shaoji ChengM Hong Nguyen
Sep 7, 2002·Molecular and Cellular Biology·Cécile DeluenMartine A Collart
Dec 4, 2003·Molecular and Cellular Biology·Vijay RamaswamyMichael C Schultz
Jun 10, 2004·Microbiology and Molecular Biology Reviews : MMBR·Joseph V GrayMargaret Werner-Washburne
Jan 3, 2012·Genetics·Kevin A MoranoW Scott Moye-Rowley
Oct 27, 2011·Gene·Martine A Collart, Olesya O Panasenko
Jan 5, 2011·Protein & Cell·Mark Bartlam, Tadashi Yamamoto
Jan 22, 2005·Molecular Microbiology·Johnny RoosenJoris Winderickx
May 6, 2004·Annals of the New York Academy of Sciences·Keshav K SinghLene Juel Rasmussen
Jun 11, 2011·FEMS Microbiology Reviews·Claudio De Virgilio
Jun 7, 2014·Frontiers in Genetics·Kun XuMark G Bartlam
Jul 12, 2002·Yeast
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·James FlanaganGeorgia Chenevix-Trench
Aug 24, 2006·The Journal of Biological Chemistry·Olesya PanasenkoMartine A Collart
Nov 29, 2015·Biochemical Society Transactions·Zoltan Villanyi, Martine A Collart
Aug 14, 2020·Wiley Interdisciplinary Reviews. RNA·Yong-Bin Yan
Sep 6, 2014·Genetics·Colin A ChavelPaul J Cullen
Mar 16, 2012·Critical Reviews in Biochemistry and Molecular Biology·Jason E Miller, Joseph C Reese
Aug 31, 2018·FEMS Yeast Research·Nicoletta GuaragnellaSergio Giannattasio

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