PMID: 7490289Nov 1, 1995Paper

Saccharomyces cerevisiae cells execute a default pathway to select a mate in the absence of pheromone gradients

The Journal of Cell Biology
R DorerL H Hartwell


During conjugation, haploid S. cerevisiae cells find one another by polarizing their growth toward each other along gradients of pheromone (chemotropism). We demonstrate that yeast cells exhibit a second mating behavior: when their receptors are saturated with pheromone, wild-type a cells execute a default pathway and select a mate at random. These matings are less efficient than chemotropic matings, are induced by the same dose of pheromone that induces shmoo formation, and appear to use a site near the incipient bud site for polarization. We show that the SPA2 gene is specifically required for the default pathway: spa2 delta mutants cannot mate if pheromone concentrations are high and gradients are absent, but can mate if gradients are present. ste2 delta, sst2 delta, and far1 delta mutants are chemotropism-defective and therefore must choose a mate by using a default pathway; consistent with this deduction, these strains require SPA2 to mate. In addition, our results suggest that far1 mutants are chemotropism-defective because their mating polarity is fixed at the incipient bud site, suggesting that the FAR1 gene is required for inhibiting the use of the incipient bud site during chemotropic mating. These observations reveal...Continue Reading


Feb 1, 1979·The Journal of Cell Biology·J S Tkacz, V L MacKay
Nov 1, 1977·The Journal of Cell Biology·B J Reid, L H Hartwell
Jan 1, 1992·Annual Review of Biochemistry·J Kurjan
Apr 1, 1992·Molecular Biology of the Cell·F Chang, I Herskowitz
Jan 1, 1991·Annual Review of Cell Biology·L MarshI Herskowitz
Jun 28, 1991·Cell·D G Drubin
Jan 1, 1990·Molecular and Cellular Biology·M WhitewayD Y Thomas
Apr 1, 1989·The Journal of Cell Biology·M Snyder
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A Bender, J R Pringle
Jan 1, 1988·Annual Review of Cell Biology·P N Devreotes, S H Zigmond
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·V L MacKayM L Parker
Nov 1, 1995·The Journal of Cell Biology·N ValtzI Herskowitz
Apr 1, 1995·Current Opinion in Cell Biology·D E Levin, B Errede
May 1, 1995·The Journal of Cell Biology·J Chant, J R Pringle
May 1, 1995·The Journal of Cell Biology·J ChantJ R Pringle
Nov 1, 1994·Molecular Biology of the Cell·J Chenevert
Oct 6, 1994·Nature·J B GurdonP Lemaire
Aug 1, 1994·Current Opinion in Genetics & Development·J R Priess
Aug 1, 1994·Current Opinion in Genetics & Development·E M Meyerowitz
Sep 1, 1994·Trends in Genetics : TIG·J Chant
Jul 1, 1993·The Journal of Cell Biology·E G FlescherM Snyder
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J E Segall
May 1, 1993·Genes & Development·J D McKinneyF R Cross

❮ Previous
Next ❯


Aug 1, 1996·Current Opinion in Cell Biology·J Chant
Feb 1, 1996·Current Opinion in Cell Biology·M S LongtineJ R Pringle
Feb 1, 1997·Current Opinion in Genetics & Development·E LebererM Whiteway
Feb 13, 2001·Current Biology : CB·J M White, M D Rose
Nov 1, 1995·The Journal of Cell Biology·N ValtzI Herskowitz
Dec 1, 1996·The Journal of Cell Biology·V BrizzioM D Rose
Nov 6, 2007·Molecular Biology of the Cell·Shelly C Strickfaden, Peter M Pryciak
Mar 26, 2010·Molecular Biology of the Cell·Dmitry V SuchkovDavid E Stone
Mar 8, 2013·Open Biology·Laura MerliniSophie G Martin
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Robert A Arkowitz
Dec 31, 1997·Genes & Development·J L BrownM Peter
Aug 27, 2011·Science Signaling·Meng JinTimothy C Elston
Apr 25, 2013·Science Signaling·Rodrigo BaltanásAlejandro Colman-Lerner
Aug 11, 2004·Eukaryotic Cell·Sophie BaraleRobert A Arkowitz
Aug 31, 2012·Microbiology and Molecular Biology Reviews : MMBR·Susan Michaelis, Jemima Barrowman
Oct 6, 1998·Annual Review of Biochemistry·E CabibT Drgon
Jan 19, 1999·Annual Review of Microbiology·K Madden, M Snyder
Jun 20, 2008·Genetics·Marguerite P AndersenDaniel E Gottschling
Mar 14, 1998·The Journal of Cell Biology·S ErdmanM Snyder
Mar 24, 1999·The Journal of Cell Biology·A Nern, R A Arkowitz
Apr 12, 2015·Biochimica Et Biophysica Acta·Alan M Tartakoff
Aug 30, 2008·Current Biology : CB·Satoe Takahashi, Peter M Pryciak
Dec 4, 2012·Current Biology : CB·Felipe O Bendezú, Sophie G Martin
Jun 10, 2008·Molecular Cell·Nan HaoHenrik G Dohlman
Feb 9, 1996·Cell·D G Drubin, W J Nelson
Aug 5, 2000·Fungal Genetics and Biology : FG & B·P J KostedJ E Sherwood
Aug 31, 2014·Proceedings of the National Academy of Sciences of the United States of America·Alejandra C VenturaAlejandro Colman-Lerner
Jul 13, 2016·PLoS Computational Biology·Weitao ChenChing-Shan Chou
Sep 14, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zena Hadjivasiliou, Andrew Pomiankowski
Jan 13, 1999·Yeast·J Davey

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.