Saccharomyces cerevisiae resistance to chlorinated phenoxyacetic acid herbicides involves Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes

Biochemical and Biophysical Research Communications
Miguel C Teixeira, Isabel Sá-Correia

Abstract

The transcription regulator Pdr1p is a determinant of Saccharomyces cerevisiae resistance to 2-methyl-4-chlorophenoxyacetic acid (MCPA) and 2,4-dichlorophenoxyacetic acid (2,4-D). The Pdr1p-regulated genes, TPO1 and PDR5, encoding putative multidrug transporters belonging to the major facilitator superfamily (MFS) and to the ATP-binding cassette (ABC) superfamily, respectively, are required for yeast resistance to sudden exposure to these herbicides. A rapid and transient activation of TPO1 (sixfold) and PDR5 (twofold) transcription takes place during the adaptation period preceding cell division under MCPA or 2,4-D moderate stress. These activations are mediated by both Pdr1p and Pdr3p and, as soon as adapted cells start duplication under herbicide stress, mRNA levels are drastically reduced to basal values. The longer duration of the adaptation period, observed for the Delta(pdr1) population, may involve the abolishment of the Pdr1p-mediated transcriptional activation of TPO1 and PDR5 genes, whose expression is critical to surpass the viability loss during the initial period of adaptation to the herbicides.

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Citations

Oct 20, 2010·Omics : a Journal of Integrative Biology·Nuno P MiraIsabel Sá-Correia
Jul 19, 2002·Yeast
Dec 13, 2006·The Journal of Biological Chemistry·Vivienne FardeauFrédéric Devaux
Feb 26, 2016·Applied Microbiology and Biotechnology·Jekaterina MartynovaArmands Vigants
Nov 19, 2013·Journal of Integrative Plant Biology·Yaling Song
Feb 4, 2003·The Journal of Biological Chemistry·Markus AlbertsenSabine Waffenschmidt
Apr 16, 2005·Proteomics·Miguel C TeixeiraIsabel Sá-Correia
Jan 26, 2005·The Journal of Biological Chemistry·Ken TachiharaKazuei Igarashi
May 29, 2018·Scientific Reports·Kseniia V GalkinaDmitry A Knorre
Mar 7, 2021·Fungal Genetics and Biology : FG & B·Sonam KumariRajendra Prasad
Mar 27, 2021·Biochemical and Biophysical Research Communications·Swati Swagatika, Raghuvir Singh Tomar
Mar 23, 2005·Biochemical and Biophysical Research Communications·Cristina A ViegasIsabel Sá-Correia
Jun 20, 2007·Trends in Biotechnology·Miguel Cacho TeixeiraIsabel Sá-Correia
Nov 6, 2021·Microbial Biotechnology·Clara NavarreteJosé L Martínez

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