Saccular otoconia as a cause of Ménière's disease: hypothesis based on two theories

The Journal of Laryngology and Otology
Jeremy Hornibrook

Abstract

The cause of Ménière's disease remains enigmatic after 156 years. Schuknecht's rupture and potassium intoxication theory of attacks was based on histological studies. This paper aimed to: present the most contemporary evidence indicating that ruptures do not usually occur, and discuss the possibility that detached saccular otoconia are the main cause of Ménière's disease; and to establish an unequivocal definition of the age of Ménière's disease onset. The paper reviews the electrophysiological basis of the Gibson-Arenberg drainage theory used to explain vertigo attacks. The current, limited knowledge of the likely fate of detached saccular otoconia is discussed. Electrophysiological studies during attacks do not support endolymph ruptures, but rather endolymph flowing in one direction and then in the opposite direction. Age of onset for Ménière's disease parallels that for benign paroxysmal positional vertigo. The similarity of age of onset spectrum for Ménière's disease and benign paroxysmal positional vertigo raises the possibility that the two conditions have the same fundamental cause.

References

Sep 16, 1976·Archives of Oto-rhino-laryngology·P G Lundquist
Feb 11, 1991·The Annals of Otology, Rhinology, and Laryngology·H Rask-AndersenW F House
Jan 1, 1985·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·K Ohashi, M Igarashi
Sep 1, 1983·Acta Oto-laryngologica·T ImotoD Bagger-Sjöbäck
Jul 1, 1984·Archives of Otolaryngology·U FribergD Bagger-Sjöbäck
Mar 1, 1980·Acta Oto-laryngologica·R S KimuraD D Jones
Oct 1, 1981·The Laryngoscope·J A McClureP Lycett
Mar 31, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·John S Phillips, Peter R Prinsley
Jul 9, 2009·Acta Oto-laryngologica·Hideo YamaneMatti Anniko
Mar 6, 2010·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·L ManzariI S Curthoys
Aug 18, 2010·Otolaryngologic Clinics of North America·William P R Gibson
Dec 15, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Leonardo ManzariIan S Curthoys
Aug 8, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·L ManzariI S Curthoys
Oct 16, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Audrey P CalzadaAkira Ishiyama
Sep 23, 2014·The Journal of Laryngology and Otology·D J Pender
Jan 23, 2015·The Application of Clinical Genetics·Giuseppe ChiarellaE Cassandro
Apr 29, 2015·Acta Oto-laryngologica·Hideo YamaneYuichi Inoue
Apr 29, 2016·Acta Oto-laryngologica·Sarah-Anne JohnsonJeremy Hornibrook
Dec 8, 2016·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Dario A YacovinoMaria Musazzi
Feb 2, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Jeremy Hornibrook, Philip Bird
Mar 16, 2017·The Laryngoscope·Martin Nue MøllerPer Cayé-Thomasen
Jun 21, 2017·The Journal of Laryngology and Otology·A F Jahn

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Citations

Oct 6, 2018·The Journal of Laryngology and Otology·Jonathan FishmanMusheer Hussain
May 29, 2019·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Louise DevantierHenriette Edemann-Callesen
Feb 13, 2020·Frontiers in Neurology·Louise DevantierTherese Ovesen
Mar 24, 2021·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mehdi BakhshaeeMohsen Rajati
May 23, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Christopher M SmithJeffrey T Laitman
Nov 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jeremy HornibrookChristopher M Smith

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