Sacituzumab govitecan: an antibody-drug conjugate

Expert Opinion on Biological Therapy
Sheena Sahota, Linda T Vahdat

Abstract

Despite advances in the diagnosis and treatment of patients with cancer, patients with metastatic cancer have limited therapeutic options after initial lines of therapy. Understanding tumor biology has translated into the identification of actionable targets that resulted in therapeutics. Antibody-drug conjugates (ADC) are capitalizing on this explosion of scientific information. ADCs allow an antibody to a unique target to be conjugated via an innovative linker, to a highly toxic drug which is delivered to its target. Sacituzumab govitecan is an ADC that combines the active molecule in irinotecan, SN-38, to an antibody targeting trop2. Areas covered: In this review, the authors introduce the reader to the ADC sacituzumab govitecan providing the reader with details about its pharmacokinetics, pharmacodynamics, efficacy and safety. The authors also give their expert analysis about its potential future use. Expert opinion: Sacituzumab govitecan is a novel and well-tolerated therapeutic showing promising results in difficult to treat cancers. Further studies are underway to optimize the group of patients that would benefit from it. Given its excellent performance, we are cautiously optimistic it will be approved by the FDA.

Associated Clinical Trials

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Citations

Feb 19, 2020·Expert Opinion on Therapeutic Targets·Jane S Y SuiSteven G Gray
Mar 28, 2020·American Society of Clinical Oncology Educational Book·Shalini Makawita, Funda Meric-Bernstam
Jan 4, 2020·Seminars in Cancer Biology·Biagio RicciutiMatteo Pirro
Feb 23, 2021·Therapeutic Advances in Medical Oncology·Martín Núñez AbadCarlos Camps Herrero
Mar 20, 2021·ACS Medicinal Chemistry Letters·Prasanna SivaprakasamSanjeev Gangwar
May 5, 2021·Investigative and Clinical Urology·Whi An Kwon, Ho Kyung Seo
Jan 1, 2021·Journal of Medicinal Chemistry·Mona AlasKamaljit Kaur
Aug 18, 2021·Journal of Pharmaceutical and Biomedical Analysis·David ChiuJohn Valliere-Douglass
Aug 28, 2021·Journal of Personalized Medicine·Anna BurguinFrancine Durocher

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