Sacral nerve modulation for irritable bowel syndrome: A randomized, double-blinded, placebo-controlled crossover study

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
J FassovK Krogh

Abstract

Irritable bowel syndrome (IBS) is among the most common gastrointestinal disorders, and a substantial proportion of patients have an insufficient response to treatment. In a single-blinded study, sacral nerve modulation (SNM) significantly reduced symptoms of IBS. The aim of the present double-blinded, randomized, placebo-controlled study was to evaluate the effect of SNM for IBS. We included patients with diarrhea-predominant or mixed IBS and a minimum baseline IBS-specific symptom score of 40 points (Gastrointestinal Symptom Rating Scale-IBS version). Patients underwent a 6-week period of SNM. In the first 4 weeks, the patients were randomized 1:1 to have the neurostimulator set subsensory or OFF for 2 weeks and then the opposite for another 2 weeks. Patients and investigators were blinded to settings. In the remaining 2 weeks, the stimulation was set suprasensory. IBS-specific symptoms and quality of life were assessed with validated questionnaires and bowel diaries. Twenty-one patients were randomized and eligible for analysis. The IBS-specific symptom score was reduced with borderline significance during stimulation (subsensory-OFF median change -1 (-26, 9), OFF-subsensory median change 8 (-11, 36); P = 0.0572). Pain was s...Continue Reading

References

Mar 19, 2003·Alimentary Pharmacology & Therapeutics·A P S HunginF Mearin
Oct 9, 2003·Scandinavian Journal of Gastroenterology·I K WiklundJ Naesdal
May 25, 2006·Diseases of the Colon and Rectum·Hanne B MichelsenSøren Laurberg
Mar 9, 2010·Gut·Michael A KammCor Baeten
Feb 10, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·E V Carrington, C H Knowles
Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G GourcerolM Bouvier
Sep 15, 2011·European Journal of Gastroenterology & Hepatology·Paul EnckSibylle Klosterhalfen
Mar 20, 2012·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebecca M Lovell, Alexander C Ford
Jun 29, 2012·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J WorsøeK Krogh
Oct 15, 2013·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·C MelchiorA M Leroi
Jan 22, 2014·The British Journal of Surgery·E J HorrocksC H Knowles
Jul 2, 2014·The American Journal of Gastroenterology·Olafur S PalssonWilliam E Whitehead
Sep 17, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J FassovK Krogh
Oct 16, 2015·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Line Stjernholm TipsmarkKlaus Krogh
Jun 23, 2016·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J FassovK Krogh
Aug 10, 2016·Diseases of the Colon and Rectum·Vicki PattonPhil G Dinning
Aug 23, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·S HaasK Krogh
Oct 26, 2016·The British Journal of Surgery·F ZerbibUNKNOWN CONSTIMOD study investigators
Dec 21, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·L D LangloisG Gourcerol

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Citations

Jul 9, 2020·Clinical and Experimental Gastroenterology·Janne FassovKlaus Krogh
Feb 6, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Bridget R Southwell
Jul 29, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Royce W WoodroffeSaul Wilson
Feb 17, 2021·Journal of Neural Engineering·Marina CracchioloSilvestro Micera

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