Sacubitril/valsartan in patients with heart failure with reduced ejection fraction with end-stage of renal disease.

ESC Heart Failure
Seonhwa LeeSeok-Min Kang

Abstract

Sacubitril/valsartan (SV) reduced heart failure hospitalization and cardiovascular mortality compared with enalapril in the Prospective Comparison of ARNI with ACE-I to Determine Impact on Global Mortality and Morbidity in Heart Failure trial. However, this trial excluded patients with end stage of renal disease (ESRD); thus, the efficacy and safety of SV in heart failure with reduced ejection fraction (HFrEF) with ESRD remains uncertain. We retrospectively analysed the clinical and laboratory data of 501 HFrEF patients who administered with SV from March 2017 to April 2019 in a single tertiary university hospital. A total of 23 HFrEF patients with ESRD on dialysis [58.3% non-ischaemic heart failure; left ventricular ejection fraction (LVEF): 29.7 ± 4.4%] were included in this study. At baseline and follow-up visit, we evaluated cardiovascular biomarkers such as high-sensitive troponin T (hsTnT), soluble ST2 (sST2), echocardiographic parameters, and clinical and adverse events. The mean dose of SV was 90 ± 43 mg/day at baseline and 123 ± 62 mg/day at last follow-up (follow-up duration: median 132 days). The level of hsTnT was significantly reduced from 236.2 ± 355.3 to 97.0 ± 14.0 pg/mL (P = 0.002), and the sST2 level was signi...Continue Reading

References

Sep 2, 2014·The New England Journal of Medicine·John J V McMurrayUNKNOWN PARADIGM-HF Investigators and Committees
Feb 20, 2015·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Sadayoshi ItoJack Zhang
May 28, 2016·European Journal of Clinical Pharmacology·Surya P AyalasomayajulaGangadhar Sunkara
Oct 29, 2017·Journal of the American Society of Nephrology : JASN·Ian GunsolusFred S Apple
Jan 10, 2018·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Till KellerChristiane Drechsler
Dec 1, 2018·Journal of Nephrology·Tobias FeldreichJohan Ärnlöv
Feb 7, 2019·Nephron·Javad SavojWei Ling Lau
Mar 12, 2019·Circulation·Janani RangaswamiUNKNOWN American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Clinical Cardiology
May 13, 2019·JACC. Heart Failure·Craig BalmforthJohn J V McMurray

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Citations

Jun 11, 2020·Cardiovascular Drugs and Therapy·George Chalikias, Dimitrios Tziakas
Jan 4, 2021·European Heart Journal·Héctor BuenoJohann Bauersachs
May 6, 2021·MMW Fortschritte der Medizin·Romy Langhammer, Rolf Wachter
Jul 31, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Shoichiro DaimonKazumasa Maeda

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Clinical Trials Mentioned

NCT03771729

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