Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil

Biological & Pharmaceutical Bulletin
Tatsuhiro IshidaH Kiwada

Abstract

Pharmacological treatment for cerebral ischemia and cerebral vasospasm following subarachnoid hemorrhage (SAH) cannot attain sufficiently high concentrations of the drugs in the cerebrospinal fluid (CSF) without precipitating systemic side effects. We recently developed a liposomal drug delivery system for intrathecal application that can maintain effective concentrations of cerebral vasodilator, fasudil, in the CSF. A single intrathecal injection of liposomal fasudil could maintain a therapeutic drug concentration in the CSF over a period time due to their sustained-release property, significantly decreasing infarct size in a rat model of acute ischemia and reducing vasoconstriction of the rat and dog basilar artery in a model of SAH. In this review, we are introducing our new less-invasive intrathecal drug delivery system that provides an alternative and safe method to deliver therapeutic agents.

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Citations

Apr 6, 2007·American Journal of Physiology. Renal Physiology·Yuri Ozawa, Hiroyuki Kobori
May 15, 2008·Journal of the Royal Society, Interface·Yinghui Zhong, Ravi V Bellamkonda
Mar 7, 2013·Expert Opinion on Investigational Drugs·Meihui ChenRongbiao Pi
Jan 29, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vivek GuptaFakhrul Ahsan
Jun 2, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Yi Ping ZhangChristopher B Shields
Jul 9, 2014·Journal of Neuropathology and Experimental Neurology·Lars TatenhorstPaul Lingor
Nov 15, 2008·Expert Opinion on Therapeutic Targets·Hwa Kyoung ShinCenk Ayata
Nov 7, 2014·Frontiers in Neuroscience·Yuki Fujita, Toshihide Yamashita
Apr 7, 2007·Journal of Neurosurgical Anesthesiology·Shailendra JoshiJohn Pile-Spellman
May 30, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Roberto CanaparoLoredana Serpe
Mar 7, 2020·Advanced Drug Delivery Reviews·M J FowlerR W Sirianni

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