Safe and fit genetically modified insects for pest control: from lab to field applications

Genetica
Francesca ScolariAnna R Malacrida

Abstract

Insect transgenesis is continuously being improved to increase the efficacy of population suppression and replacement strategies directed to the control of insect species of economic and sanitary interest. An essential prerequisite for the success of both pest control applications is that the fitness of the transformant individuals is not impaired, so that, once released in the field, they can efficiently compete with or even out-compete their wild-type counterparts for matings in order to reduce the population size, or to spread desirable genes into the target population. Recent research has shown that the production of fit and competitive transformants can now be achieved and that transgenes may not necessarily confer a fitness cost. In this article we review the most recent published results of the fitness assessment of different transgenic insect lines and underline the necessity to fulfill key requirements of ecological safety. Fitness evaluation studies performed in field cages and medium/large-scale rearing will validate the present encouraging laboratory results, giving an indication of the performance of the transgenic insect genotype after release in pest control programmes.

References

Dec 1, 1992·Current Opinion in Genetics & Development·M G Kidwell
Jan 1, 1989·Genome Génome / Conseil National De Recherches Canada·T F Mackay
Feb 1, 1974·Genetical Research·J M Smith, J Haigh
Jun 24, 1998·Proceedings of the National Academy of Sciences of the United States of America·Alfred M HandlerS H Saul
Jul 15, 1999·Biochemical and Biophysical Research Communications·H S LiuN J Ke
Sep 1, 1999·Insect Molecular Biology·P SundararajanDavid A O'Brochta
Oct 27, 1999·Proceedings of the National Academy of Sciences of the United States of America·I K JordanJ F McDonald
Jul 6, 2000·Nature·Flaminia CatterucciaAndrea Crisanti
Jul 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·J C Heinrich, M J Scott
Dec 9, 2000·Annual Review of Entomology·Peter W AtkinsonDavid A O'Brochta
Jan 6, 2001·Journal of Economic Entomology·P Schliekelman, F Gould
Feb 13, 2001·Insect Biochemistry and Molecular Biology·Alfred M Handler, R A Harrell
Feb 24, 2001·Annals of the New York Academy of Sciences·J H Wyss
Jun 26, 2001·Insect Molecular Biology·K MichelPeter W Atkinson
May 30, 2002·Molecular and Biochemical Parasitology·Luke Alphey, Morten H Andreasen
Aug 9, 2002·The Journal of Biological Chemistry·Luciano A MoreiraM Jacobs-Lorena
Oct 5, 2002·Science·Thomas W ScottChristophe Boëte
Oct 5, 2002·Science·Luke AlpheyFrank H Collins
Dec 17, 2002·Nature Biotechnology·Carsten Horn, Ernst A Wimmer
Feb 22, 2003·Science·Flaminia CatterucciaAndrea Crisanti
Aug 7, 2003·Trends in Parasitology·Mark Q Benedict, Alan S Robinson
Sep 25, 2003·The Journal of Experimental Biology·David A O'BrochtaPeter W Atkinson
Jan 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nic IrvinPeter W Atkinson
Feb 26, 2004·Nature Genetics·Stephen T ThibaultJonathan Margolis
Apr 6, 2004·Current Biology : CB·Matthew W Hahn, Sergey V Nuzhdin
Jul 29, 2004·Journal of Economic Entomology·M L AllenS R Skoda
Aug 13, 2004·Proceedings. Biological Sciences·Steven P Sinkins, H Charles J Godfray
Dec 21, 2004·Journal of Medical Entomology·Akio MoriDavid W Severson
Jan 25, 2005·Trends in Parasitology·Anthony A James
Mar 2, 2005·Nature Reviews. Genetics·Koen J T Venken, Hugo J Bellen
Sep 17, 2005·Insect Molecular Biology·Jason L Rasgon, Fred Gould
Oct 26, 2005·Nature Biotechnology·Flaminia CatterucciaAndrea Crisanti
Mar 11, 2006·Evolution; International Journal of Organic Evolution·H HurdP Eggleston
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Alexander W E FranzKen E Olson
Mar 17, 2006·Journal of Economic Entomology·M L Allen, Philip J Scholl
Mar 28, 2006·Trends in Parasitology·Mauro T MarrelliM Jacobs-Lorena
Apr 28, 2006·Insect Molecular Biology·Derric NimmoP Eggleston
May 10, 2006·Nature Reviews. Genetics·Steven P Sinkins, Fred Gould
Feb 27, 2007·Nature Biotechnology·Guoliang FuLuke Alphey
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mauro T MarrelliM Jacobs-Lorena
Mar 22, 2007·BMC Biology·Hoang Kim PhucLuke Alphey
Apr 19, 2007·Evolution; International Journal of Organic Evolution·Yunxin HuangFred Gould
Aug 30, 2007·Nucleic Acids Research·Nikolai WindbichlerAndrea Crisanti
Sep 27, 2007·Insect Molecular Biology·Kirsty C CondonLuke Alphey
Oct 6, 2007·Insect Biochemistry and Molecular Biology·Kirsty C CondonLuke Alphey
Jan 1, 2008·Trends in Parasitology·Louis LambrechtsChristophe Boëte
Feb 26, 2008·Nucleic Acids Research·Adam WilliamsDimitris Kioussis
May 31, 2008·Advances in Experimental Medicine and Biology·Mark Q Benedict, Alan S Robinson
Oct 18, 2008·Theoretical Population Biology·Laith YakobMichael B Bonsall
Apr 2, 2009·Medical and Veterinary Entomology·Alfred M HandlerS R Skoda
Oct 16, 2009·Proceedings of the National Academy of Sciences of the United States of America·Marc F ScheteligErnst A Wimmer
Feb 16, 2010·Transgenic Research·Maíra N SantosLuciano A Moreira
Feb 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Guoliang FuLuke Alphey

Citations

Jul 6, 2014·PLoS Neglected Tropical Diseases·Kenichi W OkamotoAlun L Lloyd
Dec 14, 2011·Annual Review of Entomology·M J Fraser
Apr 19, 2016·Evolutionary Applications·Philip T LeftwichTracey Chapman
Jul 31, 2012·Journal of Invertebrate Pathology·Adly M M Abd-AllaSerap Aksoy
May 19, 2012·Pathogens and Global Health·T A KleinMark Q Benedict
Dec 13, 2019·Journal of Experimental Botany·Christian Silva-SanzanaFrancisca Blanco-Herrera

Related Concepts

Metazoa
Insect Control
Insecta
Neomalthusianism
Gene Transfer Techniques
Genetic Fitness
Drug Evaluation
Genes
Insecta
Surgical Replantation

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