Safe and prolonged survival with long-term exposure to pomalidomide in relapsed/refractory myeloma

Annals of Oncology : Official Journal of the European Society for Medical Oncology
G FouquetIFM (Intergroupe Francophone du Myélome)

Abstract

The IFM2009-02 trial studied pomalidomide (4 mg daily, 21/28 versus 28/28) and dexamethasone in very advanced relapsed or refractory multiple myeloma (RRMM). We observed that 40% of patients had a prolonged progression-free survival (PFS) and subsequently overall survival (OS). We sought to analyze the characteristics of these patients and study the effect of long exposure to pomalidomide. We separated the studied population into two groups: 3 months to 1 year (<1 year) and more than 1 year (≥1 year) of treatment with pomalidomide and dexamethasone based on clinical judgment and historical control studies. We then analyzed the characteristics of patients according to duration of treatment. The overall response rate (ORR) for the <1-year group was 43%, the median PFS 4.6 months [95% confidence interval (95% CI) 3.8-6.4] with only 6% at 12 months, and the median OS was 15 months (11.7-20.3) and 40% at 18 months. For the ≥1-year group, the response rate and survival were strikingly different, ORR at 83%, median PFS 20.7 months (14.7-35.4), median OS not reached, and 91% at 18 months. Pomalidomide and dexamethasone favored prolonged and safe exposure to treatment in 40% of heavily treated and end-stage RRMM, a paradigm shift in the...Continue Reading

References

Jul 13, 2004·Mayo Clinic Proceedings·Shaji K KumarPhilip R Greipp
Jun 22, 2013·Critical Reviews in Oncology/hematology·Paul G RichardsonMartha Q Lacy
Sep 10, 2013·Blood Cancer Journal·A A Chanan-KhanM Q Lacy

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Citations

Jan 31, 2018·International Journal of Hematology·Yayoi Matsumura-KimotoUNKNOWN Kansai Myeloma Forum Investigators
Sep 10, 2016·F1000Research·Binod DhakalParameswaran Hari
Jun 14, 2016·American Journal of Hematology·S Vincent Rajkumar
Jan 27, 2019·Molecular and Clinical Oncology·Eiseki UsamiTomoaki Yoshimura
Jul 12, 2021·Translational Oncology·Akanksha FarswanAtul Sharma

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