Safe use of sorafenib in a patient undergoing salvage liver transplantation for recurrent hepatocellular carcinoma after hepatic resection.

Medical Oncology
Richard KimFederico Aucejo

Abstract

Sorafenib, a multikinase inhibitor targeting angiogenesis, cell survival, and proliferation in hepatocellular carcinoma (HCC) is a standard therapy for advanced stage disease. However, its utilization as neoadjuvant therapy is under investigation and remains an off label indication. The use of sorafenib in pre-liver transplant setting raises caveats associated with risk of bleeding, wound healing deficiencies, and hepatic decompensation. Herein, we report the case of a patient who after exhibiting HCC relapse post-hepatic resection underwent sorafenib therapy and subsequent transplantation. Sorafenib was well tolerated, and no adverse events were noticed. The use of sorafenib as neoadjuvant therapy in pre-transplant patients is feasible and deserves investigation in large clinical settings.

References

Mar 14, 1996·The New England Journal of Medicine·V MazzaferroL Gennari
Dec 12, 2003·Lancet·Josep M LlovetJordi Bruix
Jul 11, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Gerd OttoMichael Pitton
Aug 4, 2007·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Heung Kyu KoKyu-Bo Sung
Oct 19, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zhi Li WangDe Jiang Yu
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetUNKNOWN SHARP Investigators Study Group
Aug 9, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Francis Y YaoJohn P Roberts
Apr 29, 2010·Current Oncology Reports·Bernardino RamponeGiuseppe Confuorto

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Citations

Aug 29, 2012·Journal of Surgical Oncology·Ji-Hua ShiPål-Dag Line
Aug 14, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Katharina StauferMartina Sterneck
May 9, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giulia CastelliFabio Farinati
Oct 15, 2018·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Marco Sanduzzi-ZamparelliMaría Reig

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