PMID: 9188282Jun 1, 1997Paper

Safety analysis: relative risks of ultraviolet exposure from fluorescence spectroscopy and colposcopy are comparable

Photochemistry and Photobiology
C K BrooknerRebecca Richards-Kortum

Abstract

Fluorescence spectroscopy is a promising tool for use in the diagnosis of disease in human tissue. However, few published reports have evaluated the safety of this technique, despite the fact that many spectroscopic systems use UV illumination. This study determined the relative risk associated with light exposure from spectroscopic systems compared with the traditional light sources that are used to illuminate tissue and direct biopsies. We compared spectroscopic detection systems for the cervix to the colposcope, a low-power microscope routinely used to illuminate the cervix, which does not cause any known photochemical damage. We measured the average spectral irradiance (W/[cm2nm]) and the average tissue exposure time during a diagnostic colposcopy examination. To quantify the relative risks, we multiplied illumination spectra by several action spectra from the literature and compared the areas under the curves corresponding to each procedure. The risk associated with the average power colposcope served as our basis for comparison. We conclude that the risks of illumination using spectroscopic systems are lower than or comparable to those already encountered in routine diagnostic procedures such as colposcopy with an average...Continue Reading

References

Sep 1, 1992·The Journal of Infectious Diseases·J F RooneyA L Notkins
Jan 1, 1992·Lasers in Surgery and Medicine·K T SchomackerT F Deutsch
Jun 1, 1991·Photochemistry and Photobiology·R Richards-KortumM S Feld
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·P T WongB Rigas
Nov 1, 1994·Journal of the American Academy of Dermatology·T D HornJ Z Beer
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·N RamanujamR Richards-Kortum
Aug 1, 1994·Journal of Photochemistry and Photobiology. B, Biology·B J Vermeer, M Hurks
Jun 1, 1994·Chemico-biological Interactions·E Vicenzi, G Poli
Jan 1, 1993·Lasers in Surgery and Medicine·A MahadevanR R Richards-Kortum
Jan 1, 1994·Gynecologic Oncology·N RamanujamR Richards-Kortum
Jan 1, 1993·Environmental and Molecular Mutagenesis·F E AhmedN Setlow
Jan 1, 1995·Lasers in Surgery and Medicine·J R MourantT Shimada
Aug 1, 1996·Photochemistry and Photobiology·B Z ZmudzkaJ Z Beer

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Citations

Nov 5, 2002·Current Opinion in Chemical Biology·Konstantin SokolovRebecca Richards-Kortum
Jan 25, 2003·Journal of Biomedical Optics·Urs Utzinger, Rebecca R Richards-Kortum
Jul 11, 2006·Journal of Biomedical Optics·Kevin T SchomackerRoss F Flewelling
Aug 10, 2000·Neoplasia : an International Journal for Oncology Research·N Ramanujam
Sep 11, 2010·International Journal of Cancer. Journal International Du Cancer·Scott B CantorMichele Follen
Mar 11, 2006·Journal of Biomedical Optics·P BlazkiewiczA V Zvyagin
Jan 1, 2014·Acta Histochemica Et Cytochemica·Kiichiro MiyawakiTetsuro Takamatsu
May 1, 2019·Nature Biomedical Engineering·Dale J WaterhouseSarah E Bohndiek

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