Safety and cost benefit of an accelerated infliximab infusion protocol in the treatment of ambulatory patients with inflammatory bowel diseases

Expert Opinion on Biological Therapy
Payal SaxenaRupert W Leong

Abstract

Infliximab is recommended to be infused over 2 h, but accelerated infusion rates of 30 min may improve efficiency, patient satisfaction and reduce nursing time and cost. The safety of this approach is not established. This study aims to assess the safety of accelerated infliximab infusion and determine the direct cost savings. The primary endpoint of the study was adverse events and the secondary endpoints were cost, time saving per infusion and patient satisfaction associated with an accelerated infusion protocol. One hundred and thirty-six and 342 infusions were administered to 23 and 39 patients in the standard and accelerated protocols, respectively (mean infusion times 150 and 73.4 min, respectively, p < 0.0001). The adverse reaction rate of the standard protocol was 2.2% (95% confidence interval: 0.46 - 6.57) and accelerated protocol was 3.2% (95% CI: 1.74 - 5.73; p = 0.77). The odds ratio of adverse reaction for the 30-min infusion was 0.40 (95% CI: 0.09 - 1.82). The relative direct cost of nursing was decreased by 51.1% per infusion. Patient satisfaction score of the accelerated protocol was 9.2/10 (95% CI: 8.55 - 9.76) compared to 8.5/10 (95% CI: 7.83 - 9.17) in the initiation phase (p = 0.018). Accelerated 30-min infl...Continue Reading

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Citations

Jun 21, 2015·Journal of Crohn's & Colitis·Lev LichtensteinBatia Weiss
Feb 25, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Andrea MichielanRenata D'Incà
Jun 9, 2016·Journal of Gastroenterology and Hepatology·Glen Collins
Aug 14, 2018·Journal of Medical Economics·Kyle NullMichelle Luo

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