Safety and effectiveness of apixaban in comparison to warfarin in patients with nonvalvular atrial fibrillation: a propensity-matched analysis from Japanese administrative claims data

Current Medical Research and Opinion
Shun KohsakaYasuo Terayama

Abstract

To investigate the risk of bleeding events and stroke/systemic embolism (SE) among Japanese patients with nonvalvular atrial fibrillation (NVAF), focusing on the initial dosage of apixaban and patient age. This retrospective cohort study used de-identified electronic health records based claims data from 314 acute-care hospitals in Japan. NVAF patients newly initiated on warfarin or apixaban, with no prescription during the 180-day blanking period, were eligible. Patients were allocated to receive warfarin or 5 or 2.5 mg twice daily (BID) apixaban. One-to-one propensity-score matching was used to balance patient characteristics between apixaban and warfarin. Among 31,006 eligible patients, 11,972 matched pairs were identified for apixaban versus warfarin. Mean age ± standard deviation was 77.7 ± 10.0 and 77.6 ± 10.0 years and CHADS2 score was 2.2 ± 1.4 and 2.2 ± 1.4 for warfarin and apixaban, respectively. In the apixaban cohort, 39.4% of patients received the standard dose (5 mg BID) and 60.6% received the reduced dose (2.5 mg BID). Incidence rates (events per 100 person-years) of major bleeding, any bleeding and stroke/SE were 3.7, 23.1 and 3.1, and 2.5, 18.6 and 2.0 for warfarin and apixaban cohorts, respectively. Apixaban w...Continue Reading

References

Jul 31, 2007·Journal of the American College of Cardiology·Albert Yuh-Jer ShenWansu Chen
Sep 1, 2009·The New England Journal of Medicine·Stuart J ConnollyUNKNOWN RE-LY Steering Committee and Investigators
Aug 13, 2011·The New England Journal of Medicine·Manesh R PatelUNKNOWN ROCKET AF Investigators
Aug 30, 2011·The New England Journal of Medicine·Christopher B GrangerUNKNOWN ARISTOTLE Committees and Investigators
Jul 15, 2016·Journal of the American Heart Association·Xiaoxi YaoPeter A Noseworthy
Jul 1, 2017·Journal of the American College of Cardiology·Tomohiko OnoMasahiro Suzuki
Aug 24, 2017·The Annals of Pharmacotherapy·Giavanna Russo-AlvarezMichael B Rothberg
Oct 5, 2017·Stroke; a Journal of Cerebral Circulation·Myung-Jin ChaGregory Y H Lip

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Citations

Jan 15, 2019·Stroke; a Journal of Cerebral Circulation·Matthew M BowerWengui Yu
May 16, 2020·Stroke and Vascular Neurology·Alexander Jacob SweidanWengui Yu
Aug 4, 2018·Korean Circulation Journal·Yan Guang LiGregory Yh Lip
Oct 19, 2019·Research and Practice in Thrombosis and Haemostasis·Matthew A WanatSusan M Abughosh

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