Safety and Effectiveness of Biologic Disease-Modifying Antirheumatic Drugs in Older Patients with Rheumatoid Arthritis: A Prospective Cohort Study

Drugs & Aging
Raquel FreitasMaria José Santos

Abstract

The number of older patients with rheumatoid arthritis is increasing, but data on drug effectiveness and safety in these patients are scarce. This study assessed the effectiveness and safety of biologic disease-modifying antirheumatic drugs in older patients with rheumatoid arthritis. This prospective cohort study was based on data recorded in the Rheumatic Diseases Portuguese Register (Reuma.pt). Treatment persistence, European League Against Rheumatism response at 6 and 12 months, and adverse events were compared between adult (age < 65 years), old (age 65-74 years), and very old (age ≥ 75 years) patients. In total, 2401 patients were included, of which 379 were old and 83 were very old. Older patients had higher disease activity at baseline (Disease Activity Score 28: 5.5 in adults, 5.7 in old patients, and 6 in very old patients; p = 0.02) and more comorbidities, with patients aged 65-74 years beginning biologic disease-modifying antirheumatic drugs later in the course of rheumatoid arthritis. Treatment persistence was similar in the three patient groups (p = 0.07). The European League Against Rheumatism response rates were comparable in the three groups at 6 months (81.6% of adults, 75.2% of old patients, and 81.8% of very...Continue Reading

References

Sep 10, 2005·Annals of the Rheumatic Diseases·R FleischmannP Peloso
May 2, 2007·Arthritis and Rheumatism·Stéphane GenevayUNKNOWN Physicians of the Swiss Clinical Quality Management Program for Rheumatoid Arthritis
Jul 27, 2012·Arthritis Care & Research·Jessica WiddifieldClaire Bombardier
Jun 19, 2013·Nature Reviews. Rheumatology·Annemieke M H BootsFilip De Keyser
Apr 16, 2014·Arthritis Research & Therapy·Lena InnalaSolveig Wållberg-Jonsson

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