Jan 30, 2020

Safety and Effectiveness of the Prolonged Treatment of Children with a Ketogenic Diet

Nutrients
Jana Ruiz HerreroConsuelo Pedrón Giner

Abstract

The ketogenic diet (KD) is an effective treatment against drug-resistant epilepsy in children. The KD is a diet rich in fats that produces anticonvulsant and neuroprotective effects that reduces seizures and improves the cognitive state. Nevertheless, it can produce side effects that sometimes can be serious. Further, the effect on growth is quite controversial when used for an extended period of time. The aim of this paper was to assess the effectiveness, side effects, and repercussions in the development of children who have been treated with a KD for more than 2 years. Observational descriptive study of 26 pediatric patients on a KD, with data collection at baseline, at 3, 6, and 12 months, and then once a year. Number of seizures, type of seizures, anti-seizure drugs, anthropometry, side effects, and alterations in laboratory assessment were monitored. In every assessment, about 60%-75% of the patients experienced a reduction in number of seizures of over 90%, and at least 50% experienced side effects, of which digestive issues, alteration in the lipid metabolism, and hypercalciuria were the most common. The KD significantly affected height after 2 years of treatment. The KD is an effective treatment for drug-resistant epil...Continue Reading

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Mentioned in this Paper

Drug Resistant Epilepsy
Finding
Hypercalciuria
Cognition
Growth Retardation
Seizures
Ketogenic Diet
Diet
Anticonvulsants
Adverse Effects

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