PMID: 18413618Apr 17, 2008Paper

Safety and efficacy of a testosterone metered-dose transdermal spray for treating decreased sexual satisfaction in premenopausal women: a randomized trial

Annals of Internal Medicine
Susan R DavisAndrew Humberstone

Abstract

It is not known whether premenopausal women who report low sexual satisfaction and have low circulating testosterone levels will benefit from testosterone therapy. To evaluate the effects of exogenous testosterone in premenopausal women reporting diminished sexual function. Randomized, double-blind, placebo-controlled, dose-ranging trial. 6 Australian medical centers. 261 women age 35 to 46 years who reported a decrease in satisfying sexual activity relative to their younger years and had a morning serum free testosterone level less than 3.8 pmol/L (<1.1 pg/mL). 3 different doses of testosterone administered by a metered-dose transdermal spray for 16 weeks or placebo. The primary outcome was the mean number of self-reported satisfactory sexual events (SSEs) over 28 days at week 16. The frequency of SSEs, total number of sexual events (every 4 weeks), scores from the modified Sabbatsberg Sexual Self-Rating Scale and the Psychological General Well-Being Index, and safety variables were also measured. The number of SSEs increased during the treatment period in the active treatment groups and the placebo group. The mean number of SSEs over 28 days at week 16 was statistically significantly greater for women treated with the interme...Continue Reading

Associated Clinical Trials

Jul 7, 2017·Angelica Lindén Hirschberg

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