Safety and efficacy of abobotulinumtoxinA for hemiparesis in adults with upper limb spasticity after stroke or traumatic brain injury: a double-blind randomised controlled trial

Lancet Neurology
Jean-Michel GraciesInternational AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group

Abstract

Resistance from antagonistic muscle groups might be a crucial factor reducing function in chronic hemiparesis. The resistance due to spastic co-contraction might be reduced by botulinum toxin injections. We assessed the effects of abobotulinumtoxinA injection in the upper limb muscles on muscle tone, spasticity, active movement, and function. In this randomised, placebo-controlled, double-blind study, we enrolled adults (aged 18-80 years) at least 6 months after stroke or brain trauma from 34 neurology or rehabilitation clinics in Europe and the USA. Eligible participants were randomly allocated in a 1:1:1 ratio with a computer-generated list to receive a single injection session of abobotulinumtoxinA 500 U or 1000 U or placebo into the most hypertonic muscle group among the elbow, wrist, or finger flexors (primary target muscle group [PTMG]), and into at least two additional muscle groups from the elbow, wrist, or finger flexors or shoulder extensors. Patients and investigators were masked to treatment allocation. The primary endpoint was the change in muscle tone (Modified Ashworth Scale [MAS]) in the PTMG from baseline to 4 weeks. Secondary endpoints were Physician Global Assessment (PGA) at week 4 and change from baseline t...Continue Reading

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References

Aug 9, 2002·The New England Journal of Medicine·Allison BrashearUNKNOWN Botox Post-Stroke Spasticity Study Group
Jul 9, 2004·Archives of Physical Medicine and Rehabilitation·Martin K ChildersPatricia T Molloy
Feb 17, 2005·Muscle & Nerve·Jean-Michel Gracies
Feb 17, 2005·Muscle & Nerve·Jean-Michel Gracies
Jun 28, 2006·Journal of Rehabilitation Medicine·Charles T LeonardScott A Wilkins
May 7, 2008·Neurology·D M SimpsonUNKNOWN Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology
Jul 17, 2008·Journal of Neuroengineering and Rehabilitation·Laila AlibiglouMehdi M Mirbagheri
Feb 7, 2009·Journal of Rehabilitation Medicine·Jörg WisselNiko Tieranta
Aug 1, 2009·Clinical Neuropharmacology·Petr KanovskýSusanne Grafe
Mar 20, 2010·Archives of Physical Medicine and Rehabilitation·Jean-Michel GraciesMauricio R Delgado
Apr 2, 2010·Journal of Neurology·Ryuji KajiUNKNOWN GSK1358820 Spasticity Study Group
Jul 17, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G SheeanUNKNOWN Cerebral Palsy Institute
Mar 1, 2012·Neurorehabilitation and Neural Repair·Raymond L RosalesK S Lawrence Wong
Apr 9, 2014·Archives of Physical Medicine and Rehabilitation·Jean-Michel GraciesDavid M Simpson

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Citations

Sep 1, 2015·Lancet Neurology·Gert Kwakkel, Carel G M Meskers
Sep 18, 2016·Lancet·Graeme J Hankey
Nov 24, 2016·Neurological Research·Jing WangMingyue Xiao
Jun 23, 2016·EBioMedicine·Jaap Harlaar
Jun 20, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Christina MarciniakUNKNOWN International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group
May 6, 2016·Home Healthcare Now·Teri Capriotti, Teresa Murphy
Oct 17, 2017·Der Internist·A Straube
May 29, 2018·Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy·Dursun ErbilDursun Nigar
Jul 26, 2018·Neurorehabilitation and Neural Repair·Colin K FranzCharles J Heckman
Jun 8, 2017·Muscle & Nerve·Jean-Michel GraciesUNKNOWN International AbobotulinumtoxinA Adult Upper Limb Spasticity Study Group
Aug 23, 2018·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·E V Kostenko, A N Boiko
Aug 25, 2018·Brain and Behavior·Elena AlvisiGiorgio Sandrini
Jun 22, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Michael W O'DellJean Michel Gracies
Nov 22, 2019·Neurorehabilitation and Neural Repair·Amanda Claire WallaceDavid J Werring
Nov 3, 2017·Neurology·Jean-Michel GraciesUNKNOWN International AbobotulinumtoxinA Adult Lower Limb Spasticity Study Group
Jun 25, 2020·PM & R : the Journal of Injury, Function, and Rehabilitation·Alvin H IpPatricia B Mills
Sep 17, 2016·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M A AkulovA A Tomskiy
Mar 7, 2020·Health and Quality of Life Outcomes·Klemens FheodoroffDavid M Simpson
Nov 23, 2017·The Cochrane Database of Systematic Reviews·Anneliese SynnotKate Phillips
Apr 26, 2019·Annals of Clinical and Translational Neurology·Meng WangJianan Li
Jan 1, 2019·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·S E KhatkovaA S Orlova
Oct 23, 2018·The Journal of Spinal Cord Medicine·Carlos Cruz-MontecinosSofía Pérez-Alenda
Apr 7, 2020·American Journal of Physical Medicine & Rehabilitation·Armando AlvarezGemayaret Alvarez
Dec 14, 2019·Journal of Neurologic Physical Therapy : JNPT·T George HornbyUNKNOWN and the Locomotor CPG Appraisal Team
Mar 11, 2020·Frontiers in Neurology·Johannes M N EnslinAnthony Figaji
May 31, 2017·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E M Nesbitt-HawesJ A Abbott
Aug 29, 2019·Frontiers in Neurology·Jeanette PlantinPåvel G Lindberg

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