PMID: 11323089Apr 27, 2001Paper

Safety and efficacy of acarbose in the treatment of Type 2 diabetes: data from a 5-year surveillance study

Diabetes Research and Clinical Practice
G Mertes

Abstract

This 5-year surveillance study assessed the tolerability and safety of acarbose in patients with diabetes. A total of 2035 patients were enrolled of whom 1954 were classified as having Type 2 diabetes. The study was open with no control group. Physicians had sole control of the acarbose doses prescribed. Fasting blood glucose levels, 2-h postprandial glucose levels, HbA(1) or HbA(1c) and other clinical parameters, such as lipids and liver enzyme levels, were also assessed as measures of efficacy and safety. One-third of the patients received acarbose as monotherapy and two-thirds in combination with other glucose-lowering treatment. The concomitant diseases were also assessed. Doses of acarbose were low in the majority of the patients and well tolerated. The incidence of acarbose-associated side effects was 4.7%. No sustained adverse changes in laboratory measures occurred. Over the 5 years, HbA(1) and glycated haemoglobin (HbA(1c)) decreased by 2.4 and 1.8% points, respectively, and the mean fasting glucose and 2-h postprandial glucose decreased by 2.7 and 3.4 mmol/l. Mean body weight was reduced by 0.9 kg. The results suggest that when used in long-term day-to-day management of diabetes, acarbose is well tolerated and can imp...Continue Reading

References

Apr 23, 1979·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·I HillebrandP Berchtold
Oct 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·R Tattersall
Jan 1, 1996·Diabetic Medicine : a Journal of the British Diabetic Association·J L Chiasson
Aug 26, 1998·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·H LaubeP Heyen
Jun 5, 2010·Current Diabetes Reviews·Wafaa BenallaMohamed Bnouham

❮ Previous
Next ❯

Citations

Dec 18, 2001·Diabetes/metabolism Research and Reviews·B NazlielB Koçer
Mar 1, 2008·Cardiovascular Drugs and Therapy·Markolf HanefeldCarsta Koehler
Apr 23, 2003·Diabetes Research and Clinical Practice·Chii-Min HwuUNKNOWN Asian Acarbose Study Group
Sep 11, 2003·Diabetes Research and Clinical Practice·Chang-Yu PanHua Cheng
Jun 18, 2003·Journal of Diabetes and Its Complications·Boniface J LinUNKNOWN Writing Group for the Asian Study of Acarbose with Sulfonylureas
Oct 11, 2007·Diabetes, Obesity & Metabolism·O SchnellUNKNOWN Acarbose-Insulin Combination Study Group
Nov 18, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Marie-Eve ParadisBenoît Lamarche
Jan 22, 2011·BMC Complementary and Alternative Medicine·Sudha PAmeeta R Kumar
May 12, 2007·The Review of Diabetic Studies : RDS·Ken YajimaTakao Saruta
Oct 25, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Christoph Rosak, Gabriele Mertes
Nov 17, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yusuke IkumiMitsuru Akashi
Apr 7, 2010·Expert Opinion on Drug Metabolism & Toxicology·Shibashish GiriAugustinus Bader
Mar 17, 2015·Nutrition & Metabolism·Marc J MathewsEdward H Mathews
Jan 22, 2011·Diabetes Research and Clinical Practice·Chunlin LiBirgit Schmidt
Feb 11, 2015·The Annals of Pharmacotherapy·Linda TranErin E Thompson
Dec 14, 2006·Clinical Drug Investigation·Yi-Jen HungHarald Landen
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
May 30, 2007·Clinical Drug Investigation·Dieter NeuserDieter Petzinna
May 30, 2007·Clinical Drug Investigation·Pesach SegalManfred Spengler
May 31, 2007·Clinical Drug Investigation·K R KlockeH Landen
May 31, 2007·Clinical Drug Investigation·Werner BachmannUNKNOWN European Acarbose Study Group
Feb 6, 2008·Expert Review of Cardiovascular Therapy·Markolf Hanefeld, Frank Schaper
Oct 9, 2019·Expert Opinion on Pharmacotherapy·Maka S Hedrington, Stephen N Davis
Aug 11, 2015·Expert Opinion on Pharmacotherapy·Shashank R JoshiRahul Rathod
Aug 14, 2003·Der Internist·E Windler
Jul 10, 2007·The American Journal of Clinical Nutrition·Jennifer A WilliamsVikkie A Mustad

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Type 2 Diabetes

Biomarkers can help understand chronic diseases and assist in risk prediction for prevention and early detection of diseases. Here is the latest research on biomarkers in type 2 diabetes, a disease in which the body is unable to produce or properly use insulin.