Safety and efficacy of adding intravenous N-acetylcysteine to parenteral L-alanyl-L-glutamine in hospitalized patients undergoing surgery of the colon: a randomized controlled trial

Annals of Saudi Medicine
Manal El HamamsyGhada Hussein Eladly

Abstract

Colon surgery can cause systemic inflammatory response syndrome (SIRS). There is a recent trend towards the use of antioxidant agents in the prevention or alleviation of the severity of postoperative SIRS, but its use is controversial as studies have shown conflicting results. Investigate the efficacy and tolerability of perioperative intravenous administration of N-acetylcysteine (NAC) as an antioxidant and anti-inflammatory agent in patients undergoing colon surgery. Randomized, double-blinded, and controlled clinical trial. Surgical critical care unit in Egypt. Sixty patients who required admission to the ICU following colon surgery were enrolled in the study between July 2015 and October 2016. Eligibility included the need for parenteral nutrition for at least 5 days due to failure of or contraindication to enteral nutrition. Patients were randomly allocated using a computer-generated list to a loading dose of NAC followed by continuous infusion started one hour prior to induction, and continued over 48 hours, or to the control group, who received the same volume of dextrose 5%. Allocation was concealed using opaque, sealed envelopes under pharmacy control. The researcher, the anesthesiologist, the surgeon, and patients wer...Continue Reading

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Citations

Apr 8, 2021·Journal of Research in Medical Sciences : the Official Journal of Isfahan University of Medical Sciences·Najmolsadat AtefiAzadeh Goodarzi
Jul 3, 2021·JPEN. Journal of Parenteral and Enteral Nutrition·Maryam GholamalizadehSaeid Doaei

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Methods Mentioned

BETA
MDA
enzyme linked immunosorbent assay

Clinical Trials Mentioned

NCT03589495

Software Mentioned

SPSS
PASS

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