Safety and efficacy of addition of hyaluronidase to a mixture of lidocaine and bupivacaine in scalp nerves block in elective craniotomy operations; comparative study

BMC Anesthesiology
Ahmed Abdalla MohamedBadawy Mohamed AlKholy

Abstract

Patients undergoing craniotomy operations are prone to various noxious stimuli, many strategies are commenced to provide state of analgesia, for better control of the stress response and to overcome its undesired effects on the haemodynamics and post-operative pain. Scalp nerves block are considered one of these strategies. This study was conceived to evaluate the effect of addition of hyaluronidase to the local anaesthetic mixture used in the scalp nerves block in patients undergoing elective craniotomy operations. 64 patients undergoing elective craniotomy operations were enrolled in this prospective randomized, double-blind comparative study. Patients were randomly assigned to two groups. Group LA, patients subjected to scalp nerves block with 15 ml bupivacaine 0.5%, 15 ml lidocaine 2%, in 1:400000 epinephrine. Group H as Group LA with15 IU /ml Hyaluronidase. Patients in the H group showed lower VAS values for 8 h postoperative, compared to the LA group. The haemodynamic response showed lower values in the H group, compared to the LA group. Those effects were shown in the intraoperative period and for 6 h post-operative. No difference was detected regarding the incidence of complications nor the safety profile. Our data supp...Continue Reading

References

Jan 1, 1992·British Journal of Anaesthesia·J F KeelerS P Kay
Sep 26, 2000·The Journal of Thoracic and Cardiovascular Surgery·P R EvoraH V Schaff
Apr 28, 2010·Expert Opinion on Biological Therapy·Amber L DunnMiles Day
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May 11, 2016·Clinical Neurology and Neurosurgery·Ozlem Korkmaz DilmenErcument Yentur
Jan 4, 2017·Anaesthesia·K OdeA F Smith

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Citations

Nov 21, 2019·The Cochrane Database of Systematic Reviews·Imelda M GalvinIan Gilron
Jul 16, 2019·Current Opinion in Anaesthesiology·Vin Shen BanDavid L McDonagh
Feb 4, 2021·Annals of Gastroenterological Surgery·Ryota KoyamaToshiki Shinohara
Dec 8, 2021·Postgraduate Medicine·Caterina AurilioManlio Barbarisi

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Clinical Trials Mentioned

NCT03411330

Software Mentioned

Medcalc
SPSS

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