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Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

Lancet Neurology

Nov 13, 2019

Gregory L. KraussMarc Kamin

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Abstract

More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizure freedom are needed. Cenobamate (YKP3089), an investigational antiepileptic drug, has shown broad-spectrum anticonvulsant activity in preclinical studies and sei...read more

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Anticonvulsants
Antiepileptic Agents
Awareness
Clinical Investigators
Double-Blind Method
Emergency Treatment
Eosinophilia
Epilepsy
Randomization
Adverse Reaction to Drug
36
30
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Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

Lancet Neurology

Nov 13, 2019

Gregory L. KraussMarc Kamin

PMID: 31734103

DOI: 10.1016/s1474-4422(19)30399-0

Abstract

More than a third of patients with epilepsy are treatment resistant, and thus new, more effective therapies to achieve seizure freedom are needed. Cenobamate (YKP3089), an investigational antiepileptic drug, has shown broad-spectrum anticonvulsant activity in preclinical studies and sei...read more

Mentioned in this Paper

Anticonvulsants
Antiepileptic Agents
Awareness
Clinical Investigators
Double-Blind Method
36
30

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