Safety and efficacy of anti-tumor necrosis factors α in patients with psoriasis and chronic hepatitis C

World Journal of Clinical Cases
Monica SalviAntonio Giovanni Richetta

Abstract

Up to date, in literature, it is still debated the role of anti-tumor necrosis factors (TNF)-α treatments in hepatitis C virus (HCV) patients. TNF-α performs a lot of functions, it is an important pro-inflammatory cytokine and it is involved in the host's immunity. Since TNF-α is implicated in the apoptotic signaling pathway of hepatocytes infected by HCV, anti TNF-α therapy may increase the risk of viral replication or their reactivation. However the treatment of anti TNF-α could have a healthful role because TNF-α appears to be engaged in the pathogenesis of liver fibrosis, inducing apoptotic pathways. We describe the case of a patient with plaque-type psoriasis and concomitant chronic HCV, who was treated successfully with anti-TNF agents simultaneously to cyclosporine without sign of reactivation of HCV and increase of liver enzymes. Our personal experience shows that anti-TNF-α agents are not only effective but also safe. Furthermore the combination therapy of cyclosporine and anti-TNF-α appears to be well-tolerated and able to reduce the amount of liver enzymes as well as HCV-viral-load. However systematic, large-scale studies with long follow-ups will be needed to confirm our results, in association with close liver func...Continue Reading

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Citations

Jan 19, 2018·The Journal of Dermatological Treatment·Nawaf AlMutairi, Hesham Alaadin Abouzaid
Nov 22, 2018·The British Journal of Dermatology·S A R SiegelA Ortega Loayza
Sep 9, 2016·World Journal of Gastroenterology : WJG·Claudio BonifatiLorenzo Nosotti
Mar 3, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Claudia LindhausPeter Elsner
Mar 3, 2017·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Claudia LindhausPeter Elsner
Aug 1, 2018·International Journal of Molecular Sciences·Loris Riccardo LopetusoAlfredo Papa
Jan 1, 2018·European Journal of Hospital Pharmacy. Science and Practice·Virginia Martinez-SantanaInmaculada Torre-Lloverás
Sep 22, 2018·JAAD Case Reports·Diana Velázquez Tarjuelo, Pablo de la Cueva Dobao

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