Abstract
We performed post-marketing surveillance to evaluate the safety and efficacy of cell-free and concentrated ascites reinfusion therapy (CART). In total, 356 CART sessions in 147 patients at 22 centers were performed. The most common primary disease was cancer (128 cases, 300 sessions). Mean amount of ascites collected was 3.7 L, and mean concentration ratio was 9.2. Mean amount of reinfused protein was 67.8 g (recovery rate, 72.0%). Performance status, dietary intake, urine volume, body weight and abdominal circumference were significantly improved after CART. Body temperature increased significantly, by 0.3°C on average. Concomitant steroids and/or NSAIDs use before reinfusion was significantly and negatively associated with increases in body temperature. Most adverse events were fever and chills. This study examined a large number of patients compared with previous studies, and showed that CART is an effective and relatively safe treatment for refractory ascites, such as malignant ascites.
References
Jan 1, 1978·The Annals of Thoracic Surgery·P HallowellE Lowenstein
Dec 1, 1992·Kidney International·D SchneditzU Binswanger
Aug 1, 1992·Annals of Internal Medicine·B A RunyonJ G McHutchison
Jan 1, 1985·Progress in Neurobiology·M J Dascombe
Feb 6, 1999·Critical Care Medicine·D ErnestP M Dodek
Feb 24, 2001·Zeitschrift für Gastroenterologie·D ZaakR Kuhn
Jun 21, 2002·The New England Journal of Medicine·Richard W Light
Mar 1, 1939·The Journal of Clinical Investigation·H A Davis, J F Blalock
Sep 1, 1947·The Journal of Clinical Investigation·S E Bradley, G P Bradley
Jan 22, 2008·Journal of the American College of Cardiology·Wilfried MullensW H Wilson Tang
Feb 25, 2011·International Journal of Clinical Oncology·UNKNOWN Japanese CART Study GroupYasuaki Gyoda
Sep 3, 2011·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Syouji OrimiMasami Hashimoto
Jul 31, 2012·Journal of the American College of Cardiology·Claudio RoncoPeter A McCullough
Feb 7, 2014·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Tetsuya ItoMasaomi Nangaku
Sep 23, 2014·International Journal of Clinical Oncology·Tetsuya ItoKiyoshi Miyagawa
Oct 4, 2014·Molecular and Clinical Oncology·Osamu MaedaHidemi Goto
May 20, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H YamaguchiT Watanabe
Jul 16, 2015·The Journal of Obstetrics and Gynaecology Research·Liangcheng WangHiroyuki Seki
Sep 20, 2015·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Sayako MaedaKunihiko Hirose
Citations
Jan 13, 2018·Internal Medicine·Hanako TsurumiShunya Uchida
Apr 30, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Atsushi OhashiMidori Hasegawa
Jul 12, 2019·Internal Medicine·Motoh IwasaYoshiyuki Takei
Apr 4, 2020·Artificial Organs·Keisuke Matsusaki, Kazumasa Orihashi
Jun 17, 2020·Expert Review of Anticancer Therapy·Kazuto HaradaJaffer A Ajani
Jun 12, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Hironori NakamuraMasaki Nagasawa
Jun 12, 2020·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Atsushi OhashiYukio Yuzawa
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Shuet Fong NeongFlorence Wong
Oct 23, 2019·PeerJ·Beata Kasztelan-Szczerbinska, Halina Cichoz-Lach
Apr 27, 2019·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Sachie YamadaYukio Yuzawa
Jul 17, 2019·Scientific Reports·Yosuke YamadaYuji Kamijo
Mar 19, 2020·Artificial Organs·Toshiya OkahisaTetsuji Takayama
Nov 27, 2018·International Journal of Clinical Oncology·Yoshiko KawataTomoyuki Fujii
Oct 15, 2020·Journal of Medical Case Reports·Koya YasudaMakoto Araki
Mar 25, 2021·International Journal of Clinical Oncology·Ken IshitaniNorio Hanafusa
Apr 10, 2021·Journal of Medical Ultrasonics·Naoki MatsumotoKeisuke Matsusaki
May 8, 2021·World Journal of Hepatology·Yu Jun WongTiing Leong Ang
Apr 23, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Midori HasegawaNaotake Tsuboi
Jul 13, 2021·Journal of Gastroenterology and Hepatology·Tetsuya ItoMichio Kato
Oct 25, 2021·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kenichi KogaAkira Sugawara