Safety and efficacy of co-administered diethylcarbamazine, albendazole and ivermectin during mass drug administration for lymphatic filariasis in Haiti: Results from a two-armed, open-label, cluster-randomized, community study

PLoS Neglected Tropical Diseases
Christine DubrayJean Frantz Lemoine

Abstract

In Haiti, 22 communes still require mass drug administration (MDA) to eliminate lymphatic filariasis (LF) as a public health problem. Several clinical trials have shown that a single oral dose of ivermectin (IVM), diethylcarbamazine (DEC) and albendazole (ALB) (IDA) is more effective than DEC plus ALB (DA) for clearing Wuchereria bancrofti microfilariae (Mf). We performed a cluster-randomized community study to compare the safety and efficacy of IDA and DA in an LF-endemic area in northern Haiti. Ten localities were randomized to receive either DA or IDA. Participants were monitored for adverse events (AE), parasite antigenemia, and microfilaremia. Antigen-positive participants were retested one year after MDA to assess treatment efficacy. Fewer participants (11.0%, 321/2917) experienced at least one AE after IDA compared to DA (17.3%, 491/2844, P<0.001). Most AEs were mild, and the three most common AEs reported were headaches, dizziness and abdominal pain. Serious AEs developed in three participants who received DA. Baseline prevalence for filarial antigenemia was 8.0% (239/3004) in IDA localities and 11.5% (344/2994) in DA localities (<0.001). Of those with positive antigenemia, 17.6% (42/239) in IDA localities and 20.9% (72...Continue Reading

References

Jan 11, 1991·The American Journal of Tropical Medicine and Hygiene·F O RichardsH C Spencer
Nov 15, 2011·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Deborah LaytonSaad A W Shakir
Oct 17, 2012·PLoS Neglected Tropical Diseases·Naomi DrexlerPatrick Lammie
Nov 28, 2012·Swiss Medical Weekly·Jürg UtzingerChristoph F Hatz
Sep 11, 2013·The American Journal of Tropical Medicine and Hygiene·Cédric B ChesnaisMichel Boussinesq
Jul 18, 2014·PLoS Neglected Tropical Diseases·Roland OscarMarie Denise Milord
Jul 16, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andreas FløeChristian Wejse
Dec 2, 2015·Perspectives in Clinical Research·Jagadeeswara Rao Gaddale
Dec 15, 2015·Parasites & Vectors·T Déirdre HollingsworthUNKNOWN NTD Modelling Consortium
Jan 19, 2016·The Cochrane Database of Systematic Reviews·Cesar Henriquez-CamachoMaria N Plana
Dec 26, 2016·The Lancet Infectious Diseases·Michael A IrvineT Deirdre Hollingsworth
Sep 12, 2017·PLoS Neglected Tropical Diseases·Cédric B ChesnaisGary J Weil
Oct 25, 2017·The American Journal of Tropical Medicine and Hygiene·Patrick J LammieThomas G Streit
May 23, 2018·Tropical Medicine and Health·Charlie AveEric Ottesen
Aug 11, 2018·Journal of the American Academy of Dermatology·Thomas Vazquez
Nov 8, 2018·The New England Journal of Medicine·Christopher L KingJames W Kazura
Jul 18, 2019·PLoS Neglected Tropical Diseases·Charles W GossKenneth B Schechtman

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Citations

Mar 18, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Myra HardyAndrew C Steer
Jul 30, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Christian KositzMichael Marks
Apr 28, 2021·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gabriela MatamorosAlejandro Krolewiecki
Nov 16, 2021·PLoS Neglected Tropical Diseases·Kimberly Y WonJonathan D King

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Methods Mentioned

BETA
MDA
MDAs

Software Mentioned

SAS
MedDRA
CliniOps
CliniTrial

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